2019年英国妇科内镜学会/英国皇家妇产科医师学会《妊娠期腹腔镜手术指南》解读

迄今为止，尚无妊娠期腹腔镜手术的临床指南。近期，英国妇科内镜学会（the British Society for Gynaecological Endoscopy，BSGE）和英国皇家妇产科医师学会（the Royal College of Obstetricians and Gynaecologists，RCOG）制定了本指南，适用于妊娠期非产科腹部疾病的腹腔镜管理，包括妊娠期急性阑尾炎、急性胆囊疾病和良性附件肿瘤。指南建议只有具备专业腹腔镜技术并经常进行复杂腹腔镜手术的医生可行妊娠期腹腔镜手术。 浏览更多请关注本刊微信公众号及当期杂志。

Association between TIM-1 -1454 locus polymorphism and Henoch-Schonlein purpura in children.

Objective　To assess the genetic association between the TIM-1 gene promoter region -1454G/A polymorphism and HSP in children. Methods　Genomic DNA was extracted from the peripheral leukocytes of 143 patients with HSP and 178 normal children by polymerase chain reaction-restriction fragment length polymorphism analysis and gene sequencing technology； calculate genotype and allele frequencies； analyze the relationship was found between comparison groups. Results　No significant differences in allele or genotype distribution between patients and controls. However， a significant increased frequency of allele G in -1454G/A loci was found in patients with HSP who developed renal manifestation， compared to patients without renal involvement （OR = 2.375， 95% CI = 1.168～4.830， P < 0.05）， and the genotype distibution also showed statistically significant difference （P < 0.05）. Conclusion　Although there is no association between TIM-1 -1454 SNP and HSP， this study suggest that TIM-1 -1454 SNP might be associated with susceptibility to the development of renal manifestation in patients with HSP.