Little contribution of GB virus C to the development of primary hepatocellular carcinoma in Japan |
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| Authors: | Yasumasa Nishiyama Kunihiko Hino Naoto Sawada Fumio Tsuda |
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| Affiliation: | (1) Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan, JP;(2) Department of Medicine and Laboratory Medicine, St. Marianna University School of Medicine, Kanagawa, Japan, JP;(3) Institute of Immunology, Tokyo, Japan, JP;(4) Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan, JP |
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| Abstract: | ![]()
RNA of GB virus C was searched for in sera from 109 patients with primary hepatocellular carcinoma. It was detected in 11 patients (10%), and was more frequent than in 3 of 342 blood donors (0.9%) (P < 0.001). The 11 patients included 4 of 29 patients (14%) with hepatitis B surface antigen and 7 of 74 patients (9%) with antibody to hepatitis C virus. RNA of GB virus C was not detected in any of 4 patients without hepatitis B surface antigen or antibody to hepatitis C virus. These results suggest that GB virus C may contribute little to the development of primary hepatocellular carcinoma in Japan. Received: August 3, 1998 / Accepted: February 26, 1999 |
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| Keywords: | : hepatitis viruses GB virus C hepatitis B virus hepatitis C viruses hepatocellular carcinoma |
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