The in-vitro and in-vivo characterization of PLGA:L-PLA microspheres containing dexamethasone sodium phosphate |
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| Authors: | H. EROG LU H. S. KASe L. ONER Oe . F. TUe RKOG LU N. AKALAN M. F. SARGON N. Oe ZER |
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| Affiliation: | 1. Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Sohhiye-Ankara, Turke;2. Hacettepe University, Faculty of Medicine, Department of Brain Surgery, 06100 Sohhiye-Ankara, Turkey;3. Hacettepe University, Faculty of Medicine, Department of Anatomy, 06100 Sohhiye-Ankara, Turkey;4. Hacettepe University, Faculty of Medicine, Department of Biochemistry, 06100 Sohiye-Ankara, Turkey |
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| Abstract: | Dexamethasone sodium phosphate (DSP) is a widely used corticosteroid in the treatment of brain oedema associated with brain tumours. DSP has many side effects that limit its usage at an effective concentration. The objective of this study was to minimize these side effects by encapsulating DSP using biodegradable synthetic polymers, to extend the release time from microspheres and to evaluate the effectiveness in the treatment of brain oedema. Microspheres containing 5% DSP were formulated by the solvent evaporation method by using a 1:1 mixture of two synthetic polymers, poly(lactic-co-glycolic acid) and L-polylactic acid (PLGA and L-PLA). The surface morphologies and particle size distribution of the microspheres were investigated. The in-vitro |
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| Keywords: | Dexamethasone Sodium Phosphate Microspheres Brain Oedema Plga L-PLA |
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