血管腔内治疗慢性下肢缺血时的溶栓治疗

目的 探讨导管溶栓在慢性下肢缺血腔内成形治疗时的可行性、疗效及安全性.方法 回顾性分析2009年2月～2011年2月在广州市中医院接受治疗的11例慢性下肢缺血(TASC Ⅱ D级)患者的临床资料.采用尿激酶(UK)溶栓,然后再行血管腔内治疗,对治疗后临床疗效及动脉通畅率进行统计分析.结果 9例患者(81.8％)血管成形技术获得成功,无并发症发生；2例(18.2％)未溶栓成功.8例患者获得随访,随访率为88.9％,平均随访时间14.5个月.术后1年一期通畅率、辅助一期通畅率和二期通畅率分别为80％、88％及92％,2年为67％、84％及88％.结论 对慢性下肢缺血TASC Ⅱ D级病变进行血管腔内成形时的溶栓是可行、安全且有效的.

Catheter-directed thrombolysis for the treatment of chronic limb ischemia before endovascular therapy

Objective To evaluate the feasibility, safety and efficacy of catheter-directed thrombolysis in treating chronic limb ischemia(CLI)before endovascular angioplasty. Methods From Feb. 2009 to Feb. 2011, the clinical data of 11 CLI patients (TASC Ⅱ D) who treated in Guangzhou hospital of traditional Chinese medicine were reviewed. Patients were received catheter-directed thrombolysis with urokinase before endovascular angioplasty. Results 9 cases were successfully treated without complications,and technical success rate was 81.8%, 2 cases(18.2%) was failed. Eight patients were followed up for a mean time of 14.5 months. Primary, assisted-primary, and secondary patency rates was 80%, 88% and 92% at 1 year, respectively, 67%, 84% and 88% at 2 years, respectively. Conclusion Catheter-directed thrombolysis in treating CLI (TASC Ⅱ D) before endovascular angioplasty is creditable, safe and effective.