病毒性脑炎患儿恢复期癫痫的临床表现及高危因素分析

目的 探讨病毒性脑炎患儿恢复期SEP危险因素,并评估预后.方法 对133例病毒性脑炎出院患儿进行随访,恢复期SEP患儿21例作为试验组,比较2组患儿的临床表现、脑脊液、头颅影像学及脑电图特点,分析恢复期SEP高危因素.结果 试验组癫痫发作次数、惊厥持续时间、癫痫持续状态、脑脊液HSV-1 IgG检出率、EEG中重度异常及恢复时间均高于对照组,2组比较差异有统计学意义（P＜0.05或P＜0.01）.Logistic回归分析显示,癫痫发作次数、惊厥持续时间和EEG中重度异常及恢复时间为病毒性脑炎恢复期SEP的危险因素（P＜0.05）.结论 病毒性脑炎恢复期SEP的高危因素为急性期癫痫发作次数、惊厥持续时间和EEG中重度异常及恢复时间.

Clinical features and risk factors of convalescence period of epilepsy in children with viral encephalitis

Objective To investigate the risk factors and prognosis of symptomatic epilepsy （SEP）after viral encephalitis in children. Methods The 133 cases of viral encephalitis in children were followed, the 21 cases of children with convalescent SEP were as the experimental group, and the clinical manifestation, CSF, imaging and EEG landing of two groups of children were retrospectively analyzed,to explore the risk factors of convalescent SEP. Results The frequency of seizures, duration of seizures, status epilepticus, CSF HSV-1 IgG, moderate to severe abnormalities and time of recovery with EEG of the test group were significantly higher than those in control group, there was significant difference between two groups （P~0.05 or P d0.01）. Multiplicity logistic regression analysis showed that the frequency of seizures, duration of seizures, moderate to severe abnormalities and time of recovery with EEG were risk factors of convalescent SEP （P~0.05）. Conclusion The frequency of seizures, duration of seizures, moderate to severe abnormalities and time of recovery with EEG were risk factors of SEP after viral encephalitis in children.