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恒温腹腔热灌注化疗治疗结直肠癌并恶性腹水临床疗效观察
引用本文:邹湘才,洪楚原,梁国健. 恒温腹腔热灌注化疗治疗结直肠癌并恶性腹水临床疗效观察[J]. 岭南现代临床外科, 2012, 12(5): 274-276
作者姓名:邹湘才  洪楚原  梁国健
作者单位:广州医学院第二附属医院
摘    要:
【摘要】目的 探讨恒温腹腔热灌注化疗对结直肠癌并恶性腹水的临床疗效。方法 42例结直肠癌并腹水患者行肿瘤切除术后,使用BR-TRG-Ⅰ型体腔热灌注治疗系统进行腹腔恒温热灌注化疗,水温恒定保持在42±0.5℃,化疗液为生理盐水3000ml+5-FU 2.0,灌注时间为60分钟。结果 42例患者均顺利完成热灌注化疗,未发生需要终止治疗的严重不良反应,其中腹水完全缓解24例(57.15%),部分缓解12例(28.57%),稳定4例(9.52%),无效2例(4.76%),有效率达到85.71%。结论 恒温腹腔热灌注化疗是治疗结直肠癌并恶性腹水的有效方法。

关 键 词:【关键词】腹腔热灌注  恶性腹水  结直肠癌  化疗  
收稿时间:2012-04-23

Clinical observation on homothermal peritoneal hot-perfusion chemotherapy for teating colorectal cancer associated with malignant ascites
Zou Xiangcai , Hong Chuyuan , Liang Guojian. Clinical observation on homothermal peritoneal hot-perfusion chemotherapy for teating colorectal cancer associated with malignant ascites[J]. Lingnan Modern Clinics in Surgery, 2012, 12(5): 274-276
Authors:Zou Xiangcai    Hong Chuyuan    Liang Guojian
Affiliation:.Department of Gastro-intestinal Surgery,The Second Affiliated Hospital of Guangzhou Medical College,Guangzhou 510260
Abstract:
Objective To explore the therapeutic efficacies on homothermal peritoneal hot- perfusion chemotherapy for treating colorectal cancer associated with malignant ascites. Mothods After resection of tumor in 42 cases with colorectal cancer associated with malignant ascites, the peritoneal homothermal peritoneal hot-perfusion chemotherapy was performed by the hot-perfusion system (BR- TRG-1). The water temperature was kept in 42±0.5℃. The chemotherapeutic perfusion solutions were normal saline 3000 mL plus 5-Fu 2 grans and the perfusion time was 60 minutes. Result The hot- perfusion chemotherapy was performed unevenfully in all cases. No discontinued treatment was needed clue to severe adverse reactions. Of 42 cases, the eomllete remission,partial remission, stable disease and progress disease were in 24 cases (57.15%), 12 cases (28.57%),4 cases (9.52%) and 2 cases (4.76%) respectively. The total eddeetive rate was 85.71%. Conclusion The homothermal peritoneal hot-perfusion chemotherapy has precise efficacy,lower cost and practical value.
Keywords:Peritoneal hot-perfusion  Mahgnant ascites  Colorectal cancer  Chemotherapy
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