Influence of Buyang Huanwu Decoction on activity of blood platelet activating factor receptor in rabbit) on activity of blood platelet activating factor receptor in rabbit |
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| Authors: | Zhang Jiping Li Changling Guo Xinxin Wang Yinye |
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| Affiliation: | 1. Pharmacology Department, College of Pharmacy, Beijing Medical University, Beijing
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| Abstract: | Objective: To observe the influence of Buyang Huanwu Decoction (BYHWD) on the activity of blood platelet activating factor receptor (PAFR).Methods: BYHWD was administered to rabbits in vitro or in vivo and its effect on PAFR was observed by radioligand receptor binding method.Results: BYHWD tended to increase the specific binding amount of washed-platelet-PAFR with radioligand in vivo, which was similar to that of Ginkgo leaf extract. And in vitro, it showed an inhibition on the specific binding of washed-platelet-PAFR.Conclusion: BYHWD has certain effect on PAFR amount in vivo and PAFR activity in vitro |
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