| 错配修复基因与大肠癌相关性的研究进展 |
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| 引用本文： | 赵小娟,高志芹. 错配修复基因与大肠癌相关性的研究进展[J]. 临床肿瘤学杂志, 2009, 14(7): 664-668 |
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| 作者姓名： | 赵小娟 高志芹 |
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| 作者单位： | 潍坊医学院基础医学教学部细胞生物学教研室 |
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| 摘 要： | ＤＮＡ错配修复（ｍｉｓｍａｔｃｈｒｅｐａｉｒ，ＭＭＲ）是机体内ＤＮＡ修复机制的一种重要形式，广泛存在于生物体中，在防止基因突变和维持基因组稳定性的过程中起关键作用。最早研究发现错配修复基因突变与遗传性非息肉性大肠癌的发生有密切关联。越来越多的研究发现，错配修复基因功能缺失在一部分散发性大肠癌的发生过程中也起到一定的作用。本文就错配修复基因与大肠癌相关性的研究进展作一综述。
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| 关 键 词： | 大肠癌 错配修复基因 |
| 收稿时间： | 2009-01-06 |
| 修稿时间： | 2009-03-24 |
Progression in the relationship between mismatch repair gene and colorectal carcinoma |
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| ZHAO Xiao-juan,GAO Zhi-qin. Progression in the relationship between mismatch repair gene and colorectal carcinoma[J]. Chinese Clinical Oncology, 2009, 14(7): 664-668 |
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| Authors: | ZHAO Xiao-juan GAO Zhi-qin |
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| Affiliation: | ZHAO Xiao-juan, GAO Zhi-qin.( Department of Cell Biology, Weifang Medical College, Weifang 261053, China) |
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| Abstract: | DNA mismatch repair gene is an important form of DNA repair mechanisms in body and have a strong effect on defense of gene mutation and maintenance of genome stability. Firstly the MMR mutation was found in HNPCC. More and more researches find that MMR deficiency plays a significant role in the process of some sporadic colorectal carcinoma. The essay is an overview of research progress in the relationship between mismatch repair gene and colorectal carcinoma. |
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| Keywords: | Clctalcanc Mimatchpaign |
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