| 增殖细胞核抗原在碳酸锂对抗黄曲霉毒素B1诱导大鼠肝癌过程中的表达及意义 |
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| 引用本文： | 陆爽,张爱华,黄晓欣,任渝江. 增殖细胞核抗原在碳酸锂对抗黄曲霉毒素B1诱导大鼠肝癌过程中的表达及意义[J]. 癌变．畸变．突变, 2002, 14(2): 84-86. DOI: 10.3969/j.issn.1004-616X.2002.02.005 |
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| 作者姓名： | 陆爽 张爱华 黄晓欣 任渝江 |
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| 作者单位： | 1. 贵阳医学院预防医学系毒理教研室,贵州,贵阳,550004;2. 解放军第44医院消化内科,贵州,贵阳,550009 |
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| 摘 要： | 目的与方法:应用免疫组化法检测碳酸锂(Li2CO3)对抗黄曲霉毒素B1(AFB1)诱导Wistar大鼠肝癌过程中增殖细胞核抗原(PCNA)的表达及意义.结果:PCNA在诱癌早期(实验第6周)即有表达,第9、10周显著升高,差异有显著性(P＜0.01).阳性对照组(B组)PCNA阳性率最高,碳酸锂同时给药组(C组)及先期给药组(D组)阳性率显著降低,C组阳性率略高于D组.结论:碳酸锂明显对抗AFB1诱导肝癌过程中PCNA的表达,通过抑制细胞增殖从而起到抗癌作用;PCNA的免疫组化检查有助于肿瘤的早期发现和追踪观察.
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| 关 键 词： | 增殖细胞核抗原 碳酸锂 黄曲霉毒素B1 实验性肝癌 Wistar大鼠 |
| 文章编号： | 1004-616X(2002)02-0084-03 |
| 修稿时间： | 2001-04-11 |
EXPRESSION AND SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN IN RESISTANCE OF LITHIUM CARBONATE TO AFLATOXIN B1-INDUCED HEPATOCARCINOGENESIS IN RATS |
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| Abstract: | Purpose and Methods: Using immunohistochemical assay, the expression and significance of proliferating cell nuclear antigen (PCNA) were studied in aflatoxin B-1 hepatocarcinogenesis of Wistar rats treated with lithium carbonate(Li-2CO-3). Results: The expression of PCNA occurred in the early stage of carcinogenesis and significantly increased at week 9 or 10. The positive rate of positive control group (B) was highest and that of group treated simultaneously (C) and group pre-treated with Li-2CO-3 (D) significantly decreased, but group C was higher than group D. Conclusion: It suggested that Li-2CO-3 has the effect on anti-expression of PCNA in aflatoxin B-1-induced hepatic carcinoma of the rat and can restrain cell proliferation,and that the immunohistochemical assay of PCNA may help early diagnosis and monitoring. |
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| Keywords: | proliferating cell nuclear antigen lithium carbonate aflatoxin B-1 hepatic carcinoma Wistar rat |
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