干细胞诱导分化为甲状腺细胞用于临床的可能性

背景：干细胞诱导分化为甲状腺细胞的研究较少,胚胎干细胞诱导分化为甲状腺细胞已经取得了一定的成果,但其他类型干细胞各有特点,能否诱导分化为甲状腺细胞仍待深入研究。目的：回顾分析各类干细胞的优缺点及诱导分化为甲状腺细胞的研究进展。方法：应用计算机检索1982-01/2011-04PubMed数据库相关文章,检索词＂stemcell,thyroidcells,induction,differentiation＂,并限定文章语言种类为English。同时计算机检索1982-01/2011-04万方数据库、1989-01/2011-04维普资讯网数据库和1994-01/2011-04中国知网数据库相关文章,检索词＂干细胞,甲状腺细胞,诱导,分化＂,并限定文章语言种类为中文。共检索到文献1052篇,最终纳入符合标准的文献50篇。结果与结论：不可逆性甲状腺功能减退患者需终身服用甲状腺激素,对患者的生活带来很大不便,近年来干细胞研究有望解决这些医学难题。胚胎干细胞在体外环境可诱导分化为甲状腺细胞,但受伦理学困扰和出现细胞移植排斥反应等原因其应用受到限制。其他类型干细胞各有特点,在不同的诱导条件下能够向不同的谱系分化,已广泛的用于治疗各种疾病,但未见向甲状腺细胞分化的报道。

Clinical possibility of induction and differentiation of thyroid cells from stem cells

BACKGROUND：Studies about stem cell differentiation into thyroid cells are few.Research on embryonic stem cell differentiation into thyroid cell has made some achievements,but other types of stem cells have different features of differentiation,and whether they are able or unable to differentiate into thyroid cells remains to be further studied.OBJECTIVE：To overview the advantages and disadvantages as well as progress in the research of induction and differentiation of stem cells into thyroid cells.METHODS：A computer retrieval of PubMed database（1982-01/2011-04）,Wanfang database（1982-01/2011-04）,VIP database（1989-01/2011-04）,and CNKI database（1994-01/2011-04） was done using the keywords of ＂stem cell,thyroid cells,induction,differentiation＂ in English and Chinese.A total of 1052 articles were retrieved,and finially 50 articles were included in result analysis.RESULTS AND CONCLUSION：Patients with irreversible hypothyroidism require lifelong levo-thyroxin（L-T4） replacement therapy that makes them feel discomfortable.In recent years,stem cell research is expected to solve these medical problems.Directed differentiation of embryonic stem cells may towards thyroid cells in vitro,but reject reaction and ethical issues limit the application of embryonic stem cells.Other types of stem cells have different features,they under the different induced condition can differentiate into cells of different lineage,and they have been widely used to treat various diseases.However,there are no reports about differentiation into thyroid cells.