| 简易的豚鼠皮肤单纯疱疹动物模型的建立及应用 |
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| 引用本文： | 李向群,毛琳,肖红,侯伟,文莉,杨占秋. 简易的豚鼠皮肤单纯疱疹动物模型的建立及应用[J]. 基础医学与临床, 2001, 21(2): 176-179 |
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| 作者姓名： | 李向群 毛琳 肖红 侯伟 文莉 杨占秋 |
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| 作者单位： | 湖北医科大学病毒所临床病毒室,;湖北医科大学病毒所临床病毒室,;湖北医科大学病毒所临床病毒室,;湖北医科大学病毒所临床病毒室,;湖北医科大学病毒所临床病毒室,;湖北医科大学病毒所临床病毒室, |
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| 摘 要： | 为建立简易皮肤单纯疱疹动物模型,我们用1型单纯疱疹病毒（HSV－1）经皮下注射感染豚鼠背部,并用病毒分离和PCR方法检测感染局部组织HSV－1增殖动态和DNA。结果发现在感染的第3d出现典型的单纯疱疹病变,至第14d疱疹痊愈;在感染的第2dHSV-1滴度最高,以后逐渐下降,至第10d降至最低水平,2周内均能检出HSV－1DNA。用此模型研究喷昔洛韦对单纯疱疹的疗效。结果证实PCV能明显缩短疱疹的病程,且对HSV－1增殖有抑制作用。这些结果表明该模型是简易且有效的。
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| 关 键 词： | 单纯疱疹 1型单纯疱疹病毒 动物模型 喷昔洛韦 疗效 |
| 文章编号： | 1001-6325(2001)02-0176-04 |
| 修稿时间： | 2000-02-17 |
Establishment and application of a simple guinea pig model for skin herpes simplex |
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| LI Xiang qun,MAO ling,XIAO hong,et al. Establishment and application of a simple guinea pig model for skin herpes simplex[J]. Basic Medical Sciences and Clinics, 2001, 21(2): 176-179 |
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| Authors: | LI Xiang qun MAO ling XIAO hong et al |
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| Abstract: | To establish a guinea pig model for herpes simplex, guinea pigs were inoculated subcutaneously on the back with Herpes Simplex Virus type 1(HSV 1) The virus was isolated from the tissue of the inoculated site and PCR was performed to investigate the multiplication of HSV 1 A typical lesion of herpes simplex appeared in the 3rd day after inoculation and healed in the 14th day The HSV 1 titer reached the maximum in the 2nd day, then declined, and came to the minimum on the 10th day However HSV 1 DNA could be detected throughout the two weeks The animal model was used in a study on the therapeutic effect of penciclovir (PCV) on herpes simplex The date showed that PCV could shorten the course of herpes simplex and inhibit the multiplication of HSV 1 |
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| Keywords: | herpes simples herpes simplex virus type 1 animal model penciclovir therapeutic effect |
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