慢性肾脏病患者血清Klotho蛋白、成纤维细胞生长因子-23水平与疾病严重程度的相关性分析

目的探讨Klotho蛋白及成纤维细胞生长因子(FGF)-23在慢性肾脏病(CKD)发生、发展中的作用。方法选取2014年3月至2016年3月该院收治的160例CKD患者纳入CKD组,同时将160例健康体检者纳入对照组,对2组研究对象基本临床资料、血生化指标、血清Klotho蛋白及FGF-23水平进行对比分析。结果CKD组患者血红蛋白(Hb)、血清清蛋白(ALB)、血钙(Ca)、肾小球滤过率(GFR)、Klotho蛋白水平均低于对照组,血肌酐(Cr)、血清尿素(Urea)、血磷(P)、FGF-23水平均高于对照组(P0.05)。随着CKD患者分期的进展,Hb、GFR、Klotho蛋白水平逐渐降低,Cr、Urea、P、FGF-23水平逐渐升高(P0.05)。相关性分析发现,CKD患者血清FGF-23水平与Hb、GFR、Klotho蛋白水平呈负相关(r=-0.584、0.692、-0.724),与Cr、P、Urea呈正相关(r=0.814、0.703、0.527);血清Klotho蛋白水平与Hb、GFR水平呈正相关(r=0.612、0.685),与Cr、P、Urea、FGF-23呈负相关(r=-0.720、-0.690、-0.519、0.724)。结论高水平FGF-23及低水平Klotho蛋白不仅与CKD患者钙磷代谢紊乱有关,也与CKD患者的预后有关,可能成为CKD患者的早期生物标志物及病情的预测指标。

The correlation analysis of serum levels of Klotho protein,FGF-23 and chronic kidney disease

Objective To explore the role of serum levels of Klotho protein and fibroblast growth factor(FGF)-23 in patients with chronic kidney disease(CKD).Methods A total of 160 patients with CKD were recruited into CKD group in this study,160 healthy controls were selected in the control group from March 2014 to March 2016.Basic clinical data,blood biochemical index,serum level of Klotho protein and FGF-23 were analyzed and compared between the two groups.Results The hemoglobin,serum albumin,blood calcium,glomerular filtration rate,Klotho protein levels in the CKD group were lower than those in the control group,and the serum creatinine,blood urea,blood serum phosphorus and FGF-23 were higher than those in the control group(P<0.05).With the progress of CKD stages,hemoglobin,glomerular filtration rate,Klotho protein levels gradually decreased,serum creatinine,blood urea,blood serum phosphorus,FGF-23 level increased(P<0.05).The levels of FGF-23 were negatively related to hemoglobin,glomerular filtration rate,Klotho(r=-0.584,0.692,-0.724)and were positively correlated to serum creatinine,blood urea,blood serum phosphorus(r=0.814,0.703,0.527).The levels of Klotho protein were positively related to hemoglobin,glomerular filtration rate(r=0.612,0.685),and were negatively correlated to serum creatinine,blood serum phosphorus,blood urea,FGF-23(r=-0.720,-0.690,-0.519,0.724).Conclusion High concentrations of FGF-23 and Klotho protein with low concentration were not only related to calcium phosphate metabolic disorders of patients with CKD,and were also associated with the prognosis of patients with CKD,which might be early biomarkers and predictor in patients with CKD.