早期食管鳞癌患者中微小RNA的表达差异及其临床意义研究

目的探讨早期食管鳞癌患者中微小RNA的表达差异及其临床意义。方法选取2013年4月至2016年4月收治的65例早期食管鳞癌患者作为食管鳞癌组,以及同期65例健康人作为对照组,分析微小RNA对早期食管鳞癌的诊断意义,以及微小RNA表达与化疗敏感性的关系。结果 microRNA-21、microRNA-205在食管鳞癌组中的表达水平明显高于对照组(P0.05)。microRNA-21、microRNA-205对食管鳞癌的诊断灵敏度分别为89.23%、84.62%,特异度分别为96.92%、95.38%。癌组织microRNA-21、microRNA-205高表达的患者化疗耐受性明显高于低表达患者(P0.05)。结论微小RNA可协助临床早期诊断食管鳞癌,并且可根据微小RNA的表达量,评估患者化疗的敏感性,以指导临床医师优化治疗策略。

Differential expression and clinical significance of microRNA in early esophageal squamous cell carcinoma

Objective To explore the differential expression and clinical significance of microRNA in early esophageal squamous cell carcinoma .Methods From April 2013 to April 2016 ,65 cases of early esophageal squamous cell carcinoma patients were recrui-ted into esophageal squamous cell carcinoma group ,meanwhile 65 healthy person were recruited into control group ,then analyze the significance of microRNA in the diagnosis of early esophageal squamous cell carcinoma and the relationship between the expression of microRNA and radiotherapy .Results The levels of microRNA-21 and microRNA-205 in esophageal squamous cell carcinoma group were significantly higher than those in healthy group(P<0 .05) .The sensitivities of microRNA-21 and microRNA-205 in the diagnosis of esophageal squamous cell carcinoma were 89 .23% ,84 .62% ,the specificity were 96 .92% ,95 .38% respectively .The sensitivity of radiotherapy in cancer tissues with high expression of microRNA-21 and microRNA-205 was significantly higher than that in cancer tissues with low expression (P< 0 .05) .Conclusion MicroRNA is important to assist the diagnosis of esophageal squamous cell carcinoma ,and according to the expression of microRNA ,the sensitivity to radiotherapy could be evaluated ,which could guide clinicians to select proper treatment strategies to improve therapeutic effect .