FNAB与CNB对浸润性乳腺癌的诊断价值比较

目的探索在浸润性乳腺癌的诊断过程中运用细针穿刺活检(FNAB)与空芯针穿刺活检(CNB)诊断价值的比较。方法对2015年11月至2016年11月在自贡市妇幼保健院进行诊断与治疗的100例初诊为乳腺癌患者进行穿刺活检研究,将进行FNAB的50例患者设为观察组,将进行CNB的50例患者设为对照组。以手术病理结果作为诊断金标准比较两种不同诊断方式对浸润性乳腺癌的诊断价值。术前、术后进行人表皮生长因子受体2(Her-2)、雌激素受体(ER)和孕激素受体(PR)检测。同时对比两组患者穿刺不良反应发生率。结果观察组患者共出现30例腋窝淋巴结转移,20例未见腋窝淋巴结转移,行FNAB腋窝淋巴结转移阳性病例为21例,敏感度为70.00%;对照组患者共出现29例腋窝淋巴结转移,21例未见腋窝淋巴结转移,行CNB腋窝淋巴结转移阳性病例为23例,敏感度为74.19%。观察组ER、PR、Her-2抗体与术后原发灶检测结果比较诊断符合率分别为93.55%、91.67%、92.86%,对照组分别为94.12%、92.31%、86.67%,差异均无统计学意义(P0.05);观察组穿刺后不良反应发生率(4.00%),高于对照组(0.00%)。结论在浸润性乳腺癌的诊断过程中,CNB的敏感度高于FNAB,同时两种诊断方法ER、PR、Her-2与术后原发灶检测结果均保持了较高的一致性,临床应根据患者实际情况选择合适的检查方式。

The comparison of diagnostic value of FNAB and CNB in the treatment of patients with invasive breast cancer

Objective To investigate and compare the diagnostic value of fine needle aspiration biopsy(FNAB) and core needle biopsy(CNB) in the treatment of patients with invasive breast cancer.Methods Given 100 cases of patients with newly diagnosed breast cancer biopsy in our hospital from November 2015 to November 2016,50 cases of patients with FNAB into the observation group,50 cases of patients with CNB into the control group.Taken the pathologic results as a diagnostic gold standard and compared the diagnostic value of two diagnostic methods in invasive breast cancer.Detected the human epidermal growth factor receptor 2(Her-2),estrogen receptor(ER) and progesterone receptor(PR) preoperatively and compared the adverse reactions of puncture of patients in two groups.Results 30 cases of patients in the observation group showed axillary lymph node metastasis and 20 cases of patients had no axillary lymph node metastasis,21 cases of patients were positive cases of axillary lymph node metastasis accepted FNAB examination,the sensibility was 70.00％.29 cases of patients in the control group showed axillary lymph node metastasis while 21 cases of patients didn′t have axillary lymph node metastasis,23 cases of patients were positive cases of axillary lymph node metastasis accepted FNAB examination,the sensibility was 74.19％.Compared the ER、PR、Her-2 antibody with the testing result of primary tumor after operation.The diagnostic accordance rates in the observation group were 93.55％,91.67％,92.86％ respectively.The diagnostic accordance rates in the control group were 94.12％,92.31％,86.67％,the differences in two groups were not statistical significance(P>0.05).The adverse reaction rate was 4.00％ in the observation group and 0.00％ in the control group after puncture.Conclusion The diagnostic sensibility of FNAB is poorer than CNB in the diagnostic procedure of invasive breast cancer.ER,PR,Her-2 in two diagnostic methods keep a high consistency with the testing result of primary tumor after operation.