丘脑网状核在睡眠中的作用

背景 睡眠是脑的重要功能活动之一,是人类生存的必要条件.而γ-氡基丁酸(γ-aminobutyric acid,GABA)是中枢神经系统广泛分布的一种抑制性神经递质,睡眠以及全身麻醉的产生均与GABA存在密切的关系. 目的 综述丘脑皮质系统中富含GABA神经元的丘脑网状核(thalamic reticular nucleus,TRN)在睡眠中的作用. 内容 丘脑网状核可能会通过其抑制性闸门作用调节睡眠. 趋向 TRN及其参与的丘脑-皮质环路在睡眠中的相关生理机制为睡眠及相关全身麻醉研究提供了一新靶点.

The role of thalamic reticular nucleus in sleep

Background Sleep is a restorative for brain function,meanwhile,it is a necessary procedure in our lives.γ-aminobutyric acid (GABA) is one of the inhibitory neurotransmitter,which is widely distributed in the central nervous system.It has been proved to be closely related to general anesthesia and physiological sleep.Objective To review the relationship between sleep and thalamic reticular nucleus (TRN) that contained the large numbers of GABA ergic neurons.Content The TRN acted as an inhibitory gate for information flow between the cerebral cortex and thalamus.Importantly,TRN is involved in attentional processing and sleep.Trend To explore the role of thalamic reticular nucleus as well as thalamocortical loop during sleep,and to provide new ideas for the research of sleep and general anesthesia.