人源化小鼠及其在病毒感染研究中的应用

人源化小鼠是指将人体细胞或组织移植入免疫缺陷小鼠,即保证不会产生免疫排斥,又可保证移植入的人体细胞/组织在小鼠体内作为合适的基质,适用于人体病原的感染及增殖,相较于普通动物模型可以获得更接近人体的较为可信的实验数据.目前人源化小鼠已经在病毒感染机制、诱导的免疫应答、抗病毒药物筛选及疫苗研发、基因治疗等方面的研究中获得应用,尤其对一些高度宿主特异性的病毒如HIV、HCV、DENV具有重大的研究价值.

Humanized mice and its application in the study of virus infection

Humanized mice are created by transplanting human cells or tissues into immunodeficient mice that accept human grafts without rejection.The engrafted human cells/tissues can work as effective matrix suit for the infection and proliferation of human pathogens,thus can provide more reliable results similar to human trails compared to normal animal models.Numerous studies involved the viral pathogenesis,immune responses after infection,antiviral therapy,vaccine development,and gene therapy have been conducted in this dramatical animal model,especially some human specific virus like Human Immunodeficiency Virus,Hepatitis C Virus,Dengue virus can be studied on humanized mice.