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| 小儿急性淋巴细胞白血病中枢神经系统白血病诊治现状 | |
| 引用本文： | 卢新天. 小儿急性淋巴细胞白血病中枢神经系统白血病诊治现状[J]. 临床儿科杂志, 2007, 25(8): 621-624 |
| 作者姓名： | 卢新天 |
| 作者单位： | 北京大学第一医院儿科,北京,100034 |
| 摘 要： | 中枢神经系统白血病(CNSL)的防治是小儿急性淋巴细胞白血病(ALL)治疗的一部分。诊断时高白细胞计数、T细胞型及分子遗传学为t(4;11)和Ph 是CNS复发的危险因素,脑脊液不同检查结果的预后价值有待明确。头颅放疗已不用于标危ALL患儿,头颅放疗的预防剂量已减为12Gy,鞘内及全身化疗对CNSL的治疗有重要作用。部分小儿CNS复发经挽救治疗可以长期存活,早期CNS复发的患儿应在第2次CR期进行异基因骨髓移植。 |
| 关 键 词： | 急性淋巴细胞白血病 中枢神经系统白血病 儿童 |
| 文章编号： | 1000-3606（2007）08-621-04 |
| 修稿时间： | 2007-04-09 |
Diagnosis and treatment of central nervous system leukemia in acute lymphoblastic leukemia of children |
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| LU Xin-tian. Diagnosis and treatment of central nervous system leukemia in acute lymphoblastic leukemia of children[J]. The Journal of Clinical Pediatrics, 2007, 25(8): 621-624 | |
| Authors: | LU Xin-tian |
| Affiliation: | Department of Pediatrics, The First Hospital of Beijing University, Beijing 100034, China |
| Abstract: | Control of central nervous system(CNS)leukemia is part of treatment for acute lymphoblastic leu-kemia in pediatric patients.At the time when diagnosis was made,hyperleukocytosis,T cell immunophenotype and molecular genetic abnormalities of Ph and t(4;11)are high risk factors related to CNS relapse.Prognostic significance of cerebrospinal fluid remains unclear.Cranial irradiation is no longer applied to patients of standard risk acute lymphoblastic leukemia and the dose of irradiation for prevention has reduced to 12 Gy.Intrathecal and systemic chemotherapy are important for control of CNS leukemia.Some children with CNS relapse get long-term survival after retrieval therapy.The patients with early CNS relapse should receive allogeneic bone marrow transplantation after achieving second remission. |
| Keywords: | acute lymphoblastic leukemia central nervous system leukemia children |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |