Inhibition by antiserum to vasoactive intestinal polypeptide (VIP) of prolactin secretion induced by serotonin in the rat |
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| Authors: | H Ohta Y Kato A Shimatsu K Tojo Y Kabayama T Inoue N Yanaihara H Imura |
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| Affiliation: | 1. Second Medical Clinic, Department of Medicine, Kyoto University Faculty of Medicine, Kyoto 606, Japan;71. Laboratory of Bioorganic Chemistry, Shizuoka College of Pharmacy, Shizuoka 422, Japan;1. Biological and Biomedical Sciences Program, Cornell University, Ithaca, NY 14853, USA;2. Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA;3. Cornell Neurotech, Cornell University, Ithaca, NY 14853, USA;1. Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA;1. School of Psychology, Cardiff University, 70 Park Place, CF10 3AT Cardiff, UK |
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| Abstract: | ![]()
Intraventricular (i.c.v.) injection of serotonin (5HT) or intravenous (i.v.) injection of 5-hydroxytryptophan (5HTP), a precursor of 5HT, raised plasma prolactin (PRL) levels in urethane-anesthetized rats pretreated with normal rabbit serum. When the animals were injected i.c.v. or i.v. with specific anti-VIP rabbit serum, the plasma PRL responses to 5HT and 5HTP were blunted. These findings suggest that hypothalamic VIP is involved, at least in part, in PRL secretion induced by central serotonergic stimulation in the rat. |
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