血清降钙素原及C反应蛋白检测在新生儿重症感染性疾病诊断中的应用

目的探讨血清降钙素原（PCT）及C反应蛋白（CRP）检测在新生儿重症感染性疾病诊断中的应用价值。方法选取90例新生儿,根据感染情况分为重症感染组31例,局部感染组29例,以及无任何感染依据的对照组新生儿30例,检测3组血清PCT及CRP阳性表达率及表达水平。结果血清PCT在重症感染组、局部感染组及对照组中阳性表达率逐步下降,组间差异显著（P〈0.05或P〈0.01）;血清CRP在重症感染组及局部感染组的阳性表达率显著高于对照组（P〈0.01）;血清PCT、CRP在重症感染组、局部感染组及对照组中表达水平均逐步下降,组间差异显著（P〈0.01）;血清PCT的诊断敏感度显著高于血清CRP（P〈0.05）,且血清PCT的受试者工作特征曲线下面积（0.915）显著大于血清CRP的曲线下面积（0.671）。结论血清PCT在新生儿重症感染性疾病中的诊断敏感度及准确性优于血清CRP,可作为其诊断指标之一。

Application of serum procalcitonin and C-reactive protein detections in the diagnosis of neonatal severe infectious disease

Objective To explore the application of serum procalcitonin （PCT） and C-reac- tive protein （CRP） in the diagnosis of neonatal severe infectious disease. Methods A total of 90 ne- onates were divided into severe infection group （n = 31 ） and local infection group （n =29 ） according to the infectious condition, and another 30 without any infection served as control group. The positive rates and expressions of serum PCT and CRP of all groups were detected. Results Serum PCT de- creased gradually in severe infection group and local infection group, subsequently, and the differences were significant between two groups （P 〈 0.05 or P 〈 0.01 ）. The positive rates of serum CRP were obviously higher in severe infection group and local infection group than in the control group （ P 〈 0.01 ）. Serum PCT and CRP decreased gradually in severe infection group, local infection group and the control group, subsequently, and the differences were significant among three groups （P 〈 0.01 ）. The diagnostic sensitivity of serum PCT was evidently higher than that of serum CRP （ P 〈 0.05 ）. In addition, the size under receiver operating curve （ROC） of serum PCT was 0.915, markedly higher than the 0.671 of serum CRP. Conclusion Serum PCT is superior to CRP in the diagnostic sensitivi- ty and accuracy of neonatal severe infectious diseases, thus becoming one of the diagnostic indexes.