干细胞对急性心肌梗死后心肌修复的研究进展

目前对于急性心肌梗死的治疗,主要采用药物溶栓、冠脉介入和心脏搭桥手术等方法,开通闭塞血管,恢复心肌再灌注,进而改善心肌缺血挽救濒死心肌。然而这些方法对已坏死心肌却无再生作用,最终导致缺血性心肌病的发生。最初研究显示,干细胞具有再生心肌、提高左室功能的作用,为实现心肌的有效再生带来曙光。然而随着研究的深入,干细胞的心肌再生只在动物模型中被发现,且数量极少。从临床角度来看,干细胞移植后有多种因素促进了心功能的恢复,因此心肌再生的概念已被心肌修复所替代。现就干细胞对心肌的修复作用作一综述。

Stem cells for cardiac repair in acute myocardial infarction

For the therapy of acute myocardial infarction,the main methods are pharmacological thrombolysis,percutaneous coronary intervention and cardiac bypass operation,opening the occluded vessel,recovery of myocardial reperfusion,further improving myocardial blood supply and saving dying myocardium.But all the methods can not generate new myocardiums,eventually lead to the occurrence of ischemic cardiomyopathy.Initial studies show stem cells could regenerate lost cardiomyocytes and improve left ventricular function,for realizing the effective myocardial regeneration bings hope.However,with the development of the research,the evidence for true generation of new myocardium is confined to the experimental models,and the number is very few.In the clinical perspective,myocardial regeneration has been replaced by myocardial repair,as other mechanisms seem to be involved heart function recovery.In this review,we will focus on stem cells for cardiac repair.