维吾尔族和汉族直肠癌临床病理特征及预后分析

目的：比较维吾尔族和汉族直肠癌患者的临床病理特征及预后。方法收集新疆医科大学第一附属医院2008年1月至2010年2月直肠癌患者的资料，对同期58例维吾尔族直肠癌与138例汉族直肠癌患者行临床病理特征对比分析，以比较两组患者间的预后及临床病理特征差异。结果两民族直肠癌患者性别、年龄、血型、职业、就诊时间、首发症状、组织学类型、DUKES分期差异有统计学意义（P＜0．05）；学历、伴随症状、癌胚抗原（CEA）、肿瘤部位、肿瘤直径、大体类型、分化程度、术后化疗差异无统计学意义（P＞0．05）；维吾尔族直肠癌患者5年生存率低于汉族患者（P＜0．05），并且在多因素分析模型中，民族是影响接受直肠癌根治术的患者术后生存期的独立预后因素（P＜0．05）。结论与汉族患者相比，维吾尔族直肠癌具有发病低龄化、就诊晚、分期偏晚、侵袭性强、预后差的特点。

Analysis of clinic pathological characteristics and prognosis between Uyghur and Han people with rectal cancer

Objective To study the clinic pathologic characteristics and prognosis of rectal cancer between Uyghur patients and Han patients .Methods Data of 196 cases of rectal cancer (58 Uyghur and 138 Han) in the first affiliated hospital of Xinjiang medi‐cal university from January 2008 to February 2010 was collected and analyzed .Then analyzed the differences in their clinical patho‐logical features and prognosis .Results There were significant differences in sex ,age ,blood type ,occupation ,treatment time ,the first symptom ,histological type and DUKES between two nationals (P<0 .05);while there was no significant difference in educa‐tion ,concomitant diseases ,CEA ,tumor location ,tumor size ,gross type ,degree of differentiation and postoperative chemotherapy be‐tween two nationals(P>0 .05);the 5‐year overall survival rate of the patients from Uyghur was shorter than that of the patients from Han (P<0 .05);according to the multivariate analysis ,ethnic served as an independent prognostic factor in the patients who underwent radical resection of their rectal carcinoma (P<0 .05) .Conclusion The Uyghur rectal cancer patients are associated with significantly younger age ,later treatment ,later stages ,more aggressive histopathologic characteristics and significantly worse prog‐nosis than the Han patients .