| 胰岛素对数种缩血管物质作用的影响 |
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| 引用本文： | 王峰,刘敏,王京媛,吕敏,程言亮,季小慎,卢才义,郝勇.胰岛素对数种缩血管物质作用的影响[J].中国临床药理学与治疗学,1997(2). |
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| 作者姓名： | 王峰 刘敏 王京媛 吕敏 程言亮 季小慎 卢才义 郝勇 |
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| 作者单位： | 解放军空军总医院!北京100036 |
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| 摘 要： | 目的 观察胰岛素对去甲肾上腺素、内皮素-１、氯化钾（ＫＣＩ）、血管紧张素Ⅱ和５－羟色胺缩血管作用的影响。方法 用ＳＤ大鼠的离体动脉血管观察缩血管物质的作用。结果 在含有１ｍＵ／ｍｌ胰岛素环境中，胰岛素对数种缩血管作用机制不同的物质有程度不同的血管增敏作用。对去甲肾上腺素、内皮素－１和ＫＣＩ有明显的增敏效果；对血管紧张素Ⅱ有增敏趋势，但无显著性差异；对5－羟色胺无增敏效应。结论 胰岛素在高血压的发病过程中可能起重要作用。
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| 关 键 词： | 胰岛素 血管收缩 增敏 |
Effect of insulin on several vasocontrictive agents |
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| Wang Feng,Liu Min,Wang Jingyuan,Lu Min,Cheng Yanjiang,Ji Xiaoshen,Lu Caiyi,Hao Yong.Effect of insulin on several vasocontrictive agents[J].Chinese Journal of Clinical Pharmacology and Therapeutics,1997(2). |
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| Authors: | Wang Feng Liu Min Wang Jingyuan Lu Min Cheng Yanjiang Ji Xiaoshen Lu Caiyi Hao Yong |
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| Abstract: | Aim: The effect of insulin on the vasocontrictive agents including noradrenaline, endothelin-1, KC1, angiotensin II and 5-hydroeytryptamine. was analysed. Methods Aortic rings of SD rats were used to investigate the influence of insulin for several vasocontrictive agents. Results Insulin was hypersensitive for noradrenaline, endothelin-1 and KCL, and incresed the effects of angiotensin II but no difference, but had no effect on 5-hydroxytryptamine . Canclusion It suggests insulin could play an important role in occur-rence of hypertension. |
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| Keywords: | insulin vasocontriction hypersensitivity |
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