Assessment of the Portable COPD-6 Device for Detecting Obstructive Airway Diseases |
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| Authors: | Cristina Represas Represas Maribel Botana Rial Virginia Leiro Fernández Ana Isabel González Silva Víctor del Campo Pérez Alberto Fernández-Villar |
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| Affiliation: | 1. Grupo de Investigación en Enfermedades Respiratorias e Infecciosas, Complejo Hospitalario Universitario de Vigo, Vigo, Spain;2. Servicio de Neumología, Complejo Hospitalario Universitario de Vigo, Vigo, Spain;3. Servicio de Medicina Preventiva, Complejo Hospitalario Universitario de Vigo, Vigo, Spain;4. Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Spain;1. Department of Medicine, Pulmonary Section, Hamad General Hospital and Weill-Cornell Medical College, Doha, Qatar;2. Department of Medicine, Hamad General Hospital, Doha, Qatar;3. Department of Public Health, Hamad Medical Corporation, Doha, Qatar;4. Department of Emergency Medicine, Hamad General Hospital, Doha, Qatar;1. Departamento de Neumología, Hospital Universitario Cruces, Barakaldo, Spain;2. Servicio de Evaluación de Tecnologías Sanitarias (OSTEBA), Departamento de Salud del Gobierno Vasco, Vitoria-Gasteiz, Spain;3. Departamento de Neumología, Hospital Universitario Basurto, Bilbao, Spain;4. Universidad del País Vasco (UPV-EHU) Biocruces, Hospital Universitario Cruces, Barakaldo, Spain;5. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Spain;1. Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/Universidad de Sevilla, Seville, Spain;2. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain;3. Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain |
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| Abstract: | ObjectivesTo evaluate the agreement and the association with FEV1, FEV6 and FEV1/FEV6 measured with the Vitalograph-COPD-6 portable device and the FEV1, FVC and FEV1/FVC by conventional spirometry, and to analyse the validity of this device to detect obstruction.MethodologyA cross-sectional, descriptive, prospective study, that included 180 subjects. A conventional spirometry and a spirometry with the Vitalograph-COPD-6 were sequentially performed on them. The agreement was analysed [kappa index and interclass correlation coefficient (ICC)], as well as the association [Pearson correlation coefficient (r)], area under the ROC curve (AUC) of the FEV1/FEV6 in detecting obstruction, and the sensitivity, specificity, predictive values (PPV and NPV), and probability ratios (PR+ and PR–) of the different FEV1/FEV6 cut-off points in the detection of obstruction.ResultsThe prevalence of obstruction was 47 %. The kappa index was 0.59 when an FEV1/FEV6 < cut-off point of < 0.7 was used. The ICC and the r between the FEV1 measured by the two instruments, FEV6 and FEV1/FEV6 measured by the Vitalograph-COPD-6 and the FVC and FEV1/FVC determined by the spirometer were all greater than 0.92. The ROC AUC was 0.97. To detect obstruction, if the cut-off point of FEV1/FEV6 (for COPD-6) was < 0.70, the sensitivity, specificity, PPV, NPV, CR+ and CR– were, 58 %, 100 %, 100 %, 73 %, ∞ and 0.42, respectively. For a cut-off point of < 0.8, they were 96 %, 76 %, 78 %, 96 %, 3.8 and 0.05, respectively.ConclusionsThe portable Vitalograph-COPD-6 device is precise for the detection of airway obstruction. The best sensitivity/specificity of FEV1/FEV6 was obtained with cut-off points greater than 0.7. |
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