多囊卵巢综合征患者血清内脂素游离脂肪酸水平测定及相关研究

目的：测定对多囊卵巢综合征（PCOS）患者血清中内脂素（visfatin）、游离脂肪酸（FFA）水平，研究两者之间的相关性及其与PCOS发病之间可能存在的关系。方法选择确诊PCOS的患者42例，按照体重指数分为肥胖组（1组）22例，非肥胖组（2组）20例；另因为女方输卵管因素或男方因素等来我院拟行试管的病人40例，同样按照体重指数进行划分，其中肥胖组（3组）20例，非肥胖组（4组）20例。抽取患者肘正中静脉血，对其血清中的visfatin、FFA、糖脂代谢指标等进行检测。结果visfatin在PCOS组高于对照组，1组高于2组，1组显著高于3、4组。FFA 实验组显著高于对照组。经spearman相关性分析显示，visfatin与 HDL负相关，与BM I、腰臀比、W、FINS、甘油三脂呈正相关，与其他指标无明显相关。游离脂肪酸与 HDL负相关，与TG、BMI、W、FINS、HOMI-IR、T、LPa呈正相关；Visfatin与FFA呈正相关，与其他指标无明显相关。结论 PCOS患者体内存在脂质代谢紊乱与糖代谢紊乱，PCOS肥胖型患者体内的糖脂代谢异常尤为明显，胰岛素抵抗程度更明显，内分泌激素的异常也更严重；visfatin与FFA呈正相关，均与HDL呈负相关，与TG、BMI、W、FINS、HOMI-IR呈正相关，且在PCOS患者血清中较对照组明显升高，提示两者在PCOS发病中起到一定的作用。

The determination of visfatin and free fatty acids in the serum of PCOS patients and their correlation research

Objective To determinate visfatin and free fatty acids in the serum of polycystic ovary syndromed （PCOS） pa-tients ,researching the relationship between them and the possible relationship with pathogenesis of PCOS .Methods According to the body mass index ,42 cases of patients with PCOS were selected ,which was divided into obese group （group 1） 22 cases and non obesity group （group 2） 20 cases .The other 40 patients as an control group ,who was intending to undergoing IVF ,was divided into the obese group （Group 3） 20 cases ,non obesity group （Group 4） 20 ,because female tubal factor （the fallopian tube water or blocking ） or male factors （oligospermia ,asthenospermia） ,equally according to body mass index .patients venous blood of Zhou Zheng zhong were selected ,the visfatin ,free fatty acids ,glucose and lipid metabolism in serum was detected .Re-sults Visfatin in PCOS group was higher than that in control group ,the visfatin of 1 group was higher than that in group 2 ,the visfatin of 1 group was significantly higher than that of 3 ,4 group .The FFA group was significantly higher than the control group .The Spearman correlation analysis showed that ,visfatin was negatively correlated with HDL ,and was positively correla-ted with BMI ,waist hip ratio ,W ,FINS ,glycerin three greases .and other indexes had no significant correlation .Free fatty acids was negatively correlated with HDL ,and was positively correlated with TG ,BMI ,W ,FINS ,HOMI-IR ,T ,LPa .Visfatin was positively correlated with FFA ,and with other indexes had no significant correlation .Conclusion Lipid and glucose metabolism disorder in PCOS patients in vivo is present ,glucose and lipid metabolism in obese PCOS patients is obvious ,the degree of in-sulin resistance is more obvious ,endocrine abnormalities were more severe ;visfatin was positively associated with FFA ,was negatively correlated with HDL ,was positively correlated with TG ,BMI ,and W ,FINS ,HOMI-IR .Visfatin and FFA in serum of the PCOS patients was sig