表观扩散系数与非小细胞肺癌病理基础初探

目的探讨多b值扩散加权成像的表观扩散系数（ADC值）与非小细胞肺癌病理基础的相关性。材料与方法对46例经手术病理证实的非小细胞肺癌患者行多b值扩散加权成像（DWI）扫描，计算肿瘤在不同b值时的ADC值，分析肿瘤标本的核质比、核胞比和肿瘤细胞密度，将ADC值与病理特征因子进行Pearson等级相关分析。结果任意b值时肺癌的ADC值与肿瘤细胞密度呈明显负性相关（b=300 s/mm2时，相关系数最高，r值=-0.792，P〈0.01）；肺癌的ADC值与肿瘤细胞核质比和核胞比也呈明显负性相关（b=300 s/mm2时相关性最好，r=-0.739， P〈0.01；r=-0.607，P=0.0187）。结论 ADC值与非小细胞肺癌的内部特征存在一定的相关性，可以较好地反映非小细胞肺癌的组织病理学特征。

Preliminary study on pathomechanism of non-small-cell lung carcinoma using apparent diffusion coefifcient

Objective： To investigate the value of apparent diffusion coefficient （ADC） in predicting the pathomechanism of non-small-cell lung carcinoma （NSCLC）. Materials and Methods：Four-six patients with NSCLC conformed by histopathology were examined with diffusion weighting imaging （DWI）. ADCs were calculated on multiple b-value imaging. Correlations between the ADCs and tumor cellularity, nuclear-cytoplasmic ratio and nuclear-kytoplasm ratio were analysed by Pearson rank correlation. Results：The ADCs of NSCLC correlated negatively with tumorous cellular density on multiple b-value imaging and as b was 300 s/mm2,which can achieve the best correlation （b=300 s/mm2, r=-0.792, P〈0.01）. There were inverse correlations between ADCs and nuclear-cytoplasmic ratio, nuclear-kytoplasm ratio （b=300 s/mm2, r=-0.739, P〈0.01,-0.607, P=0.0187, respectively）. Conclusions：Preliminary results revealed the ADCs of NSCLC had close correlation with tumorous histopathology characteristic.