纳洛酮联合脑活素治疗新生儿HIE效果分析

目的探讨纳洛酮联合脑活素治疗新生儿缺氧缺血性脑病的临床效果。方法将我科缺氧缺血性脑病患儿随机分为治疗组和对照组各81例，对照组给予吸氧、限制液体入量、脱水、止痉及能量合剂、胞二磷胆碱、纳络酮，治疗组在此疗法基础上加用脑活素治疗。根据临床表现、后遗症发生情况等综合评价临床效果。结果治疗组总有效率96．3％，对照组有效率88．9％。治疗组临床疗效明显高于对照组（P〈0．05），后遗症的发生率低。结论纳洛酮联合脑活素治疗新生儿缺氧缺血性脑病有协同作用，能改善脑缺血区血流灌注，促进神经细胞代谢，改善预后，减少神经系统后遗症。

Combination therapy with naloxone and cerebrolysin for hypoxic-ischemic encephalopathy in neonates

Objective To explore the efficacy of naloxone combined with cerebrolysin for hypoxic-ischemic encephalopathy in neonates. Methods 162 neonate patients were ramdonly assigned to receive oxygen inhalation, control of liquid intake, dehydration, anti-convulsion, energy mixture, citicoline,and naloxone (control group), or the former therapy plus cerebrolysin (study group, 81 neonates). The efficacy was assessed in the two goroups according to the clinical manifestations and incidence of sequelae. Results The efficacy was obviously greater in the study group than in the control group (96.3% vs. 88.9% for the effective rate, P＜0.05) and the incidence of sequelae was lower. Conclusions Naloxone combined with cerebrolysin has a synergetic effect on the treatment of hypoxic-ischemic encephalopathy in neonates. It can improve blood perfusion into the ischemic areas of the brain, promote neural cellular metabolism, improve prognosis, and reduce nervous system sequelae.