| 醋酸甲地孕酮预防放疗引起消化道反应的临床研究 |
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| 引用本文： | 梁子彬,陈燕,王思阳,丁秋娥,程志斌.醋酸甲地孕酮预防放疗引起消化道反应的临床研究[J].中国实用医药,2010,5(15):25-26. |
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| 作者姓名： | 梁子彬 陈燕 王思阳 丁秋娥 程志斌 |
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| 作者单位： | 中山大学附属第五医院肿瘤放疗科,519000 |
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| 摘 要： | 目的观察醋酸甲地孕酮（MA）在预防腹部及盆腔放疗引起的消化道反应中的作用。方法收集2008年1月至2009年12月病理学和/或细胞学证实的消化道恶性肿瘤辅助性放疗60例,采用对照研究,随机分为A和B两组。A组辅助放疗期间及放疗后1周加用MA;B组给予单纯辅助性放射治疗,观察二组放疗引起的消化道反应的差异。结果放疗同时配合使用MA厌食、恶心、呕吐发生率下降（P〈0.05）;厌食、恶心、呕吐程度改善（P〈0.001）。结论腹部及盆腔放疗同时配合使用MA可以改善患者的厌食、恶心、呕吐反应。
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| 关 键 词： | 醋酸甲地孕酮 下腹部放疗 消化道反应 |
Megestrol Acetate For Preventing Radiotherapy-induced Gastrointestinal Reactions:A Clinical Trial |
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| LIANG Zi-bin,CHEN Yan,WANG Si-yang,et al..Megestrol Acetate For Preventing Radiotherapy-induced Gastrointestinal Reactions:A Clinical Trial[J].China Practical Medical,2010,5(15):25-26. |
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| Authors: | LIANG Zi-bin CHEN Yan WANG Si-yang |
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| Institution: | LIANG Zi-bin,CHEN Yan,WANG Si-yang,et al.Department of Radiotherapy of Oncology,The fifth affiliated hospital of Sun Yat-Sen University,Guangdong,Zhuhai519000,China |
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| Abstract: | Objective To evaluate the effectiveness of megestrol acetate prevented radiotherapy-induced anorexia、nausea and vomiting.Methods Between June 2008 to December 2009 ,60 patients with abdominal cancer were randomly divided into two groups ：A and B.The patients in the A or B group respectively receive radiotherapy with or without megestrol acetate.Results Incidences of anorexia、 nausea and vomiting occurred less in patients who received megest rol acetate versus blank （P〈0. 05）.Patient s who received megestrol acetate had better improve anorexia、nausea and vomiting （P〈0. 001）.Conclusion Receiving megestrol acetate during radiotherapy can relieve digestive tract symptom. |
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| Keywords: | Megestrol acetate Abdominal radiotherapy Digestive tract symptom |
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