Effect of a sequential treatment combining abaloparatide and alendronate for the management of postmenopausal osteoporosis |
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| Authors: | J. Y. Reginster Nasser Al Daghri Jean-Marc Kaufman Olivier Bruyère |
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| Affiliation: | 1. Department of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium;2. WHO Collaborating Center, University of Liege, Liege, Belgium;3. Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia;4. Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium |
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| Abstract: | The recently published results of the sequential treatment of postmenopausal osteoporotic women with subcutaneous abaloparatide (80 µg/day) (ABL) for 18 months followed by 6 months of oral alendronate (70 mg/week) (ALN) support the administration of an anti-resorptive agent after completion of a treatment course with an osteoanabolic agent. The ABL/ALN sequence resulted in greater bone mineral density gains at all skeletal sites and in a reduction of vertebral, non-vertebral, major and clinical fractures compared to what is observed after 18 months of placebo followed by 6 months of ALN. Whereas questions remained unanswered about the ideal anti-resorptive agent to be used after ABL, the optimal duration of the administration of the anti-resorptive drug or the potential interest of re-initiating a course of ABL after a limited administration of ALN, these results support the use of the ABL/ALN sequence in the management of postmenopausal osteoporosis. |
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| Keywords: | Abaloparatide osteoporosis bisphosphonates sequential treatment fractures |
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