Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease

Authors:	Vesna Stojiljković Ana Todorović Snežana Pejić Jelena Kasapović Zorica S. Saičić Nedeljko Radlović Snežana B. Pajović

Affiliation:	1. Laboratory of Molecular Biology and Endocrinology, Vin?a Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia;2. Department of Physiology, Institute of Biological Research Sini?a Stankovi?, University of Belgrade, Belgrade, Serbia;3. University Children''s Hospital, Belgrade, Serbia;1. Laboratorio de Genética Hematológica, Instituto de Medicina Experimental (IMEX), CONICET/ANM, Academia Nacional de Medicina, Pacheco de Melo 3081, Buenos Aires C1425AUM, Capital Federal, Argentina;2. Servicio de Soporte Nutricional y Malabsorción, Hospital San Martín, 1900 La Plata, Argentina;3. Laboratorio de Genética de Neoplasias Linfoides, Instituto de Medicina Experimental (IMEX), CONICET/ANM, Buenos Aires C1425AUM, Argentina;1. Department of Internal Medicine, Southern Illinois University School of Medicine, United States;2. Department of Statistics and Research Informatics, Southern Illinois University School of Medicine, United States;3. Department of Pharmacology, Southern Illinois University School of Medicine, United States;1. Aksaray University, Faculty of Science and Arts, Department of Chemistry, Aksaray, 68100, Turkey;2. Ankara University, Faculty of Science, Department of Chemistry, Ankara, 06100, Turkey;3. Kahramanmara? Sütçü ?mam University, Faculty of Science and Arts, Department of Chemistry, Kahramanmara?, 46100, Turkey;1. Clinic of Maxillofacial Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia;2. Department of Pathology, School of Dental Medicine, University of Belgrade, Belgrade, Serbia;3. Department of Human Genetics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia;4. Department of Informatics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

Abstract:	ObjectiveTo explain the role of oxidative stress in the pathology of celiac disease.Design and methodsThe activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects.ResultsThe activities of analyzed enzymes varied significantly between the examined groups. An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. The level of lipid hydroperoxides was significantly elevated in these groups.ConclusionsOxidative stress is an important factor in the pathogenesis of celiac disease. The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease.

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