益心安神汤联合调神针法治疗脑卒中后睡眠障碍

目的:观察益心安神汤联合调神针法治疗脑卒中后睡眠障碍(post-stroke sleep disorder,PSSD)的临床疗效以及其对神经递质及应激状态的影响.方法:92例PSSD患者作为研究对象,按照随机数字表法分为对照组和试验组,各46例.两组患者均给予常规基础治疗,在此基础上对照组给予右佐匹克隆,并施以调神针刺...

Yixin Anshen Decoction Combined with Tiaoshen Acupuncture on Post-stroke Sleep Disorder

Objective:To observe the clinical efficacy of Yixin Anshen Decoction Combined with Tiaoshen acupuncture in the treatment of post-stroke sleep disorder(PSSD)and its influence on neurotransmitters and stress state.Methods:92 patients with PSSD were randomly divided into control group and experimental group with 46 cases in each group.Two groups of patients were given conventional basic treatment,on this basis,the control group was given dexzopiclone,and given Tiaoshen acupuncture;the experimental group was given Yixin Anshen Decoction on the basis of the control group.The levels of neurotransmitter and stress index were compared between the two groups,and the clinical efficacy was compared.Results:The effective rate of the experimental group was 89.13%,which was significantly higher than 71.14% of the control group(P<0.05).After treatment,two groups of TCM syndrome scores,Pittsburgh sleep quality index(PSQI),National Institute of Health stroke scale(NIHSS),Stanford Acute Stress Reaction Questionaire(SASRQ)scores were significantly reduced(P<0.05),and the treatment group was significantly lower than the control group(P<0.05).After treatment,the level of 5-hydroxytryptamine(5-HT),5-hydroxyindoleacetic acid(5-HIAA),glutamic acid(Glu),γ-aminobutyric acid(γ-GABA)of the two groups of patients was significantly increased(P<0.05),and the test group was significantly higher than the control group(P<0.05).After treatment,the two groups of adrenocorticotropic hormone(ACTH)levels significantly decreased,and the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)increased significantly.The level of ACTH in the test group was significantly lower than that of the control group(P<0.05),and the levels of SOD and GSH-Px were significantly higher than those of the control group(P<0.05).Conclusion:Yixin Anshen Decoction combined with Tiaoshen acupuncture has significant curative effect in the treatment of PSSD,which can regulate neurotransmitter disorders,reduce stress,effectively improve symptoms of sleep disorders,and promote nerve function recovery.