Propylthiouracil-Induced Leucocytoclastic Vasculitis With Pulmonary Hemorrhage Treated With Plasmapheresis |
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| Authors: | Farzan Irani Hussam Elkambergy Kalpana Naraharisetty Raheel Jamal |
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| Institution: | 1. Department of Radiology, Seoul National University Hospital, Jongno-gu, Seoul, Korea;2. Department of Radiology, Thyroid Clinic, Human Medical Imaging & Intervention Center, Seoul, Korea;3. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea;4. Department of Preventive Medicine, Graduate School of Public Health, Seoul National University Hospital, Seoul, Korea;1. Assistant Professor, Department of Oral and Maxillofacial Surgery, A B Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore, Karnataka, India;2. Professor, Department of Oral and Maxillofacial Surgery, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India;3. Assistant Professor, Department of Oral and Maxillofacial Surgery, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India;1. Department of Translational Medical Sciences, Federico II University of Naples, Naples, Italy;2. Department of Pediatric Sciences, University of Messina, Messina, Italy;3. Department of Experimental Medicine and Surgery, University of Tor Vergata and Bambino Gesù Children''s Hospital, IRCCS, Rome, 00134 Italy;4. Regional Center for Pediatric Diabetes, Clinical Nutrition and Obesity, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy;5. “B Trambusti” Paediatrics Unit, Department of Biomedical Sciences and Human Oncology, AOU Policlinico Consorziale of Bari, Bari, 70100, Italy;1. The Center of Geographic Medicine, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel;2. The Department of Internal Medicine “C”, Sheba Medical Center, Tel Hashomer 52621, Israel;3. The Arrow Project, Sheba Medical Center, Tel Hashomer 52621, Israel;4. Department of Internal Medicine “T”, Sheba Medical Center, Tel Hashomer 52621, Israel;5. Tel Aviv University, the Sackler School of Medicine, Tel-Aviv 69978, Israel |
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| Abstract: | Propylthiouracil (PTU) can effectuate antineutrophil cytoplasmic antibodies (ANCA)–positive vasculitis. We report a case of severe, PTU-induced leucocytoclastic vasculitis with diffuse pulmonary hemorrhage within a month of initiating PTU. Emergent plasmapheresis was initiated with excellent clinical response. A clinical suspicion for this potential side effect coupled with early cessation of the drug is generally adequate. Clinical manifestations, posited pathogenetic mechanisms, and therapeutic strategies, including the role of plasmapheresis, are discussed. |
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