微小RNA与肿瘤

微小RNA(miRNA)是一类小分子的非编码调控的单链RNA,它参与有机体的生长、发育等多种生理过程.近年来研究表明肿瘤组织具有不同的miRNA表达,异常表达的miRNA影响了肿瘤细胞的发生、进展、分化、转移和复发.miRNA的不同表达不仅有助于肿瘤组织的诊断,而且可以指导预后.针对miRNA为靶点的动物学研究也发现,干扰某种miRNA表达可以减小肿瘤体积,抑制腹膜转移而发挥治疗作用.

MicroRNA and tumors

MicroRNAs are a class of small(about 20-24 nueleotides),endogenous,noneoding RNA molecules that regulate a wide array of physiologic processes,such as growth and developmenL In recent years,some researches show that the tissues from tumors have aberrant mieroRNA profiling compared with normal tis-sues.The abnormal miemRNA profiling can affect the genesis,proliferation,differentiation,metastasis and recur-renee of tumors.The different expressions of microRNA Can not only help for the diagnosis of tumors,but also evaluate the prognosis of tumors.Disturbing several miemRNA expressions can decrease the volumes of tumor and inhibit the peritoneal metastasis 80 as to treat the tumor by using anti-mieroRNA drugs in animal expedments.