| 拉米夫定治疗慢性乙型肝炎失败的相关因素分析 |
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| 引用本文： | 占国清,郑三菊,朱琳,张薇薇,李刚,杜卫星.拉米夫定治疗慢性乙型肝炎失败的相关因素分析[J].临床肝胆病杂志,2009,25(3):184-186. |
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| 作者姓名： | 占国清 郑三菊 朱琳 张薇薇 李刚 杜卫星 |
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| 作者单位： | 郧阳医学院附属人民医院肝病研究室,湖北,十堰,442000 |
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| 摘 要： | 目的探讨拉米夫定治疗慢性乙型肝炎（CHB）失败的相关因素。方法回顾性分析224例拉米夫定治疗CHB患者的临床资料,根据其疗效分为失败组和成功组,比较两组年龄、性别、用药前ALT、HBV DNA水平、治疗24周后HBV DNA阴转、规则用药、HBeAg性质及HBV YMDD变异等因素。结果拉米夫定治疗失败96例,成功128例;与成功组比较,失败组治疗前ALT水平、治疗24周后HBV DNA阴转率、HBeAg阳性患者治疗中阴转和血清转换率低（P〈0.01）,治疗前HBV DNA水平和HBV YMDD变异率高,患者不规则用药（P〈0.01）,两组在年龄和性别间的差异无显著性意义（P〉0.05）。结论ALT、HBV DNA基线水平,治疗24周后HBV DNA阴转、用药规则,HBV YMDD变异及治疗后HBeAg性质改变均是影响拉米夫定治疗CHB疗效的相关因素。
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| 关 键 词： | 拉米夫定 肝炎 乙型 慢性 疗效 相关因素 |
Correlations factors involved in therapeutic failure of lamivudine for chronic hepatitis B patients. |
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| ZHAN Guo-qing,ZHENG San-ju,ZHU Lin,et al..Correlations factors involved in therapeutic failure of lamivudine for chronic hepatitis B patients.[J].Chinese Journal of Clinical Hepatology,2009,25(3):184-186. |
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| Authors: | ZHAN Guo-qing ZHENG San-ju ZHU Lin |
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| Institution: | Department of Hepatology;People Hospitol;Yunyang Medical College;Shiyan Hubei 442000;China |
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| Abstract: | Objective To investigate the correlation factors associated with therapeutic failure in chronic hepatitis B(CHB) patients who were treated with lamivudine.Methods Clinical data of 224 CHB patients treated with lamivudine were analyzed retrospectively,cases were divided into failure group and success group according to their therapeutic efficacy,the age,sex,pre-treatment levels of ALT and HBV DNA,HBV DNA negative after 24 weeks treatment,Rule medication,HBeAg and HBV YMDD variations of the two groups were co... |
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| Keywords: | Lamilvudine chronic hepatitis B curative effect correlation factor |
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