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A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) |
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| Authors: | DeWire Mariko Fuller Christine Hummel Trent R. Chow Lionel M. L. Salloum Ralph de Blank Peter Pater Luke Lawson Sarah Zhu Xiaoting Dexheimer Phil Carle Adam C. Kumar Shiva Senthil Drissi Rachid Stevenson Charles B. Lane Adam Breneman John Witte David Jones Blaise V. Leach James L. Fouladi Maryam |
| Affiliation: | 1.Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 7015, Cincinnati, OH, 45209, USA ;2.Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA ;3.Department of Hematology/Oncology, Dayton Children’s Hospital, Dayton, OH, USA ;4.Department of Radiation Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA ;5.Department of Endocrinology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA ;6.Department of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA ;7.Department of Pediatrics, Department of Psychology, College of Medicine University of Cincinnati, College of Arts and Sciences University of Cincinnati, Anderson Center Health Systems Excellence, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA ;8.Division of Neurosurgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA ;9.Department of Biostatistics, Cincinnati, OH, USA ;10.Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA ; |
| Abstract: | Journal of Neuro-Oncology - Cyclin-dependent kinase-retinoblastoma (CDK-RB) pathway is dysregulated in some diffuse intrinsic pontine gliomas (DIPG). We evaluated safety, feasibility, and early... |
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