| 高效液相色谱法测定草酸艾司西酞普兰片的含量 |
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| 引用本文： | 代亚,付涛,俞丽君,陈立萍,王贤广. 高效液相色谱法测定草酸艾司西酞普兰片的含量[J]. 中国药业, 2011, 20(16): 32-33 |
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| 作者姓名： | 代亚 付涛 俞丽君 陈立萍 王贤广 |
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| 作者单位： | 浙江海森药业有限公司,浙江,杭州,322104 |
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| 摘 要： | 目的采用高效液相色谱法测定草酸艾司西酞普兰片的含量。方法色谱柱为C18柱(250 mm×4.6 mm,5μm),流动相为磷酸盐缓冲液-甲醇(51∶49),检测波长为238 nm。结果艾司西酞普兰质量浓度在25～150μg/mL范围内与峰面积呈良好线性关系(r=0.999 9),平均回收率为99.60%,RSD为0.44%。结论该方法简便,专属性及重现性好,可用于测定草酸艾司西酞普兰片的含量。
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| 关 键 词： | 草酸艾司西酞普兰片 含量测定 高效液相色谱法 |
Determination of Escitalopram Oxalate Tablets by HPLC |
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| Dai Ya,Fu Tao,Yu Lijun,Chen Liping,Wang Xianguang. Determination of Escitalopram Oxalate Tablets by HPLC[J]. China Pharmaceuticals, 2011, 20(16): 32-33 |
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| Authors: | Dai Ya Fu Tao Yu Lijun Chen Liping Wang Xianguang |
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| Affiliation: | Dai Ya,Fu Tao,Yu Lijun,Chen Liping,Wang Xianguang(Zhejiang Haisen Pharmaceutical Co.,Ltd.,Hangzhou,Zhejiang,China 322104) |
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| Abstract: | Objective To establish a HPLC method for the assay of Escitalopram Oxalate Tablets.Methods The HPLC method was used with C18 column（250 mm×4.6 mm,5 μm）.The mobile phase was phosphoric acid buffer solution-methanol（51 ∶49）,with the detection wavelength at 238 nm.Results The linear range of escitalopram was 25-150 μg/mL（r=0.999 9）.The average recovery rate was 99.60%,RSD=0.44%. Conclusion This method is convenient with good specificity and good reproducibility for the assay of Escitalopram Oxalate Tablets. |
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| Keywords: | Escitalopram Oxalate Tablets content determination HPLC |
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