| 丁苯酞对卵白蛋白所致支气管哮喘豚鼠的影响 |
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| 引用本文： | 王志旺,程小丽,郭玫,任远,王瑞琼,段海婧,刘雪枫.丁苯酞对卵白蛋白所致支气管哮喘豚鼠的影响[J].中国现代应用药学,2016,33(12):1493-1497. |
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| 作者姓名： | 王志旺 程小丽 郭玫 任远 王瑞琼 段海婧 刘雪枫 |
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| 作者单位： | 甘肃中医药大学,甘肃中医药大学,甘肃中医药大学,甘肃中医药大学,甘肃中医药大学,甘肃中医药大学,甘肃中医药大学 |
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| 基金项目： | 国家自然科学(81460668)；甘肃省自然科学(1310RJZA086)；甘肃省中药药理与毒理学重点实验室开放(ZDSYS-KJ-2015-002) |
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| 摘 要： | 目的 探讨丁苯酞对卵白蛋白所致支气管哮喘豚鼠模型的影响。方法 采用卵白蛋白经致敏与激发两步来复制支气管哮喘豚鼠模型,通过药物干预,观测丁苯酞对哮喘豚鼠的行为学、肺功能、BALF中炎性细胞、肺组织病理学及IgE的影响。结果 30、60、120mg?kg-1丁苯酞能降低哮喘豚鼠的哮喘行为学评分、肺组织湿干重比值、BALF中炎性细胞及血清T-IgE水平,改善肺功能,缓解肺组织病理学变化(P＜0.05, 0.01)。结论 丁苯酞具有缓解肺部炎症而治疗支气管哮喘的作用。
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| 关 键 词： | 丁苯酞 哮喘 豚鼠 炎症 |
| 收稿时间： | 2016/6/24 0:00:00 |
| 修稿时间： | 2016/12/4 0:00:00 |
Effects of Butylphthalide on Bronchial Asthma in Guinea Pigs Induced by Ovalbumin |
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| WANG Zhiwang,CHENG Xiaoli,GUO Mei,REN Yuan,WANG Ruiqiong,DUAN Haijing and LIU Xuefeng.Effects of Butylphthalide on Bronchial Asthma in Guinea Pigs Induced by Ovalbumin[J].The Chinese Journal of Modern Applied Pharmacy,2016,33(12):1493-1497. |
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| Authors: | WANG Zhiwang CHENG Xiaoli GUO Mei REN Yuan WANG Ruiqiong DUAN Haijing and LIU Xuefeng |
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| Institution: | Gansu University of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine |
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| Abstract: | OBJECTIVE To study the effects of butylphthalide on model of bronchial asthma in guinea pigs induced by ovalbumin. METHODS Replicated the model of bronchial asthma in guinea pigs through sensitization and excitation, the effects of butylphthalide were evaluated through behaviors of asthma, pulmonary function, inflammatory cells, IgE and pulmonary histopathology. RESULTS The 30, 60, 120 mg·kg-1 butylphthalide could decrease asthmatic behavior score, lung wet-dry ratio, the number of inflammatory cells in BALF and IgE in serum, improve lung function, and alleviate the pathological changes of lung tissue. CONCLUSION Butylphthalide has anti-asthma effect on guinea pig partly because of relieving pulmonary inflammation. |
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| Keywords: | Butylphthalide asthma guinea pig inflammation |
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