脑灌注成像预测溶栓后出血转化风险的研究进展

出血转化是缺血性卒中的常见并发症之一，其中溶栓治疗导致继发性出血转化风险明显增加是困扰临床医生的重要问题。目前认为血脑屏障的破坏在出血转化的发生中起到关键的作用。近来研究显示，急性期的灌注影像检查对于出血转化高风险人群检出可能具有更高的敏感性和其他优势。本文针对灌注成像在预测急性缺血性卒中患者溶栓后出血转化的研究进展方面做一综述。

Advance of Perfusion Imaging in Predicting Hemorrhagic Transformation after Thrombolytic Therapy for Acute Ischemic Stroke

Hemorrhagic transformation (HT) is a serious complication of ischemic stroke.
The mechanism of HT is thought to be endothelial injury and blood-brain barrier disruption due
to severe ischemia. Recent studies have demonstrated that perfusing imaging is useful in the
pretreatment prediction of HT, and is more strongly associated and may allow better prediction of
HT when compared with CT or diffusion imaging. This article reviews the studies that evaluated
different perfusion imaging parameters as predictors of HT in acute ischemic stroke with the aim to
facilitate obtaining the reliable therapy strategies for acute ischemic stroke and improving patient
selection for acute reperfusion therapy.