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放射和顺铂伍用治疗肿瘤
引用本文:鲍云华,袁小潮,吴进冬,张伟京,张海英. 放射和顺铂伍用治疗肿瘤[J]. 军事医学科学院院刊, 1989, 0(1)
作者姓名:鲍云华  袁小潮  吴进冬  张伟京  张海英
作者单位:军事医学科学院附属医院,军事医学科学院附属医院,军事医学科学院附属医院,军事医学科学院附属医院,军事医学科学院附属医院 进修医生
摘    要:
本文报告顺铂作为放射增敏剂治疗28例恶性肿瘤的初步结果.所有病例都有肿瘤客观反应.完全缓解率74.1%,部分缓解率25.9%.肺癌17例,完全缓解64.7%,部分缓解35.3%.虽然病例数不够多,但取得的结果是令人鼓舞的.主要副作用有恶心、呕吐,骨髓功能抑制.但肾功能无损伤.顺铂伍用放疗值得在临床进一步作对照研究.

关 键 词:顺铂  放射增敏剂  放射治疗  抗癌药  低氧细胞

RADIOTHERAPY AND CISPLATIN COMBINED IN THE TREATMENT OF MALIGNANT TUMORS
Bao Yunhua,Yuan Xiaochao,Wu Jindong,Zhang Weijing,Zhang Haiying Research Clinic,Academy of Military Medical Sciences. RADIOTHERAPY AND CISPLATIN COMBINED IN THE TREATMENT OF MALIGNANT TUMORS[J]. Bulletin of the Academy of Military Medical Sciences, 1989, 0(1)
Authors:Bao Yunhua  Yuan Xiaochao  Wu Jindong  Zhang Weijing  Zhang Haiying Research Clinic  Academy of Military Medical Sciences
Abstract:
28 patients with malignant tumors were treated with radiotherapy and cisplatin.The dose of cisplatin was 20mg twice per week,the total dose ranged from 160-320mg.Radiation therapy was administered by ~(60)Co unit with total dose of 55-70Gy.Objective tumor response was observed in all patients following treatment.Complete and partial remission rates were 74% and 26% respectively.Toxic effects were moderated and consisted of emesis and myelosuppression.Further controlled studies are recommended.
Keywords:cisplatin  radiosensitizer  radiotherapy  antineoplastic agent  hypoxic cell
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