糖尿病肾病患者血清LPO、VC和VE的对照观察

本实验测定了８７例糖尿病人（早期肾病组２４例，临床肾病组１１例，无肾病组５２例和３０例正常人的血清过氧化脂质、维生素Ｃ、维生素Ｅ水平。结果显示：糖尿病各级血清过氧化脂质水平明显高于正常对照组；血清维生素Ｃ水平明显低于正常对照组，并随糖尿病肾病的进展逐渐减少，早期肾病组和临床肾病组显著低于糖尿病无肾病组；血清维生素Ｅ浓度无明显变化。提示糖尿病肾病的发生、发展与脂质过氧化增强及维生素Ｃ缺乏有关。

OBSERVATlON OF THE LEVELS OFSERUAI LlPID PEROXIDE, VITAMINE CAND VITAMINE E IN PATIENTS WITHDIABETIC NEPHROPATHY

he levels of serum lipid peroxide,vitamine Cand vitamine E of 87 diabetic patients (24 in theearly nephropathy group, 11 in the clinical nonephropathy group) and of 30 normal controls weredetermined.The results showed that the levels ofserum lipid peroxide in diabetic groups were obvi-ously higher than in the control group ;the levels ofserum vitamine C was lower than in the controlgroup, decreased with the progression of diabeticnephropathy.The levels of serum vitamine C in theearly nephropathy group and the clinical nephropa-thy group were significant lower than in the nonephropathy group. There was no obvious changein the concentration of serum vitamine E. it sug-gested that the deficiency of vitamine C and devel-opment of lipid peroxide were related to the produc-ing and development of diabetic nephropathy.