结合应激理论探讨补中益气汤治疗脾胃气虚型不寐

从现代医学角度理解,饮食结构改变、劳累过度、情绪刺激、免疫力低下等病因作为应激原,参与应激过程,致HPA轴及LC-SP-AM系统激活,神经递质失衡,破坏睡眠-觉醒节律,使机体出现失眠(不寐)。中医学认为,以上病因可致机体脾胃内伤而产生不寐症状。故结合现代医学研究,将不寐的发生发展与应激之生理病理过程、脾胃内伤之病机联系在一起,治以健脾益气、调和脾胃之法,以补中益气汤为代表方,对防治不寐及其伴随病症具有重要意义。

Discussion on Buzhong Yiqi Decoction Treating Insomnia of Spleen and Stomach Qi Deficiency Based on Stress Theory

Based on modern medicine,improper diet,over strain,emotional stimuli or low immunity are the pathogenic factors in the progress of stress in which the hypothalamic-pituitary-adrenal(HPA) axis and locus ceruleus-sympatheticoadreno-adrenal medullary(LC-SP-AM) were activated. Therefore,there appears disorder of neurotransmitters,and the sleep-wake rhythm is interfered,resulting into insomnia. In traditional Chinese medicine,all the above factors can lead to the spleen and stomach Qi deficiency,resulting into insomnia.Combined with modern medical research,the occurrence and development of insomnia,the progress of chronic stress,and internal injury of spleen and stomach are connected. The treatment is invigorating spleen,supplementing Qi,and harmonizing the function of spleen and stomach. Buzhong Yiqi decoction is the formula for this disease,and it is important for the prevention and treatment of insomnia and the involved disease.