卡维地洛对阿霉素心脏毒性的保护作用

阿霉素(adriamycin ADR)是最有效的广谱抗癌药物之一,但是,ADR严重的心脏毒性限制了其临床应用。ADR心脏毒性发生发展过程中氧化应激和细胞凋亡发挥重要作用,卡维地洛(carvedilol,CVD)是一种具有抗氧化、抗细胞凋亡的β受体阻滞剂。在该研究中探讨了卡维地洛对阿霉素心脏毒性的保护作用及其可能的机制。通过检测血流动力学、检测血清中超氧化物歧化酶的活性和丙二醛含量、检测心肌细胞凋亡,研究表明卡维地洛能改善阿霉索引起的血流动力学异常,通过抑制阿霉素引起的机体内过度的氧化应激及心肌细胞凋亡,卡维地洛对阿霉素引起心脏毒性具有潜在的保护作用。

Protective Effects of Carvedilol against the Adriamycin-induced Cardiotoxicity

The clinical use ofadriamycin,a highly active anticancer drug,is limited by its severe cardiotoxic side effects.Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity of adriamycin. Carvedilol is an adrenergic blocking agent with potent anti-oxidant activity and apoptosis.In this study we investi- gated whether carvediloi has protective effects against adriamycin-induced rat cardiotoxicity and is explored its possible mechanism,the changes of rat cardiac function,the activity of superoxide dismutase and the contents of malondialdehyde in serum as well as myocardial cell apoptosis were detected.Our results suggest that carvedilol relieves adriamycin-induced hemodynamic abnormality mainly by improving cardiac systolic and diastolic function. Our results suggest that carvedilol is potentially protective against adriamycin cardiotoxicity by decreasing free radical release and apoptosis in cardiomyocytes.