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| 甲基强的松龙对大鼠脊髓损伤后微管相关蛋白-2表达的影响 | |
| 引用本文： | 马延超,董平,钱军,汉华,汪玉良. 甲基强的松龙对大鼠脊髓损伤后微管相关蛋白-2表达的影响[J]. 兰州大学学报(医学版), 2010, 36(1): 1-4 |
| 作者姓名： | 马延超 董平 钱军 汉华 汪玉良 |
| 作者单位： | 兰州大学第二医院,骨科,甘肃,兰州730030;张掖市人民医院,骨科,甘肃,张掖734000 |
| 摘 要： | 目的研究甲基强的松龙对大鼠脊髓损伤后微管相关蛋白-2（MAP-2）表达的影响。方法健康成年wistar大鼠66只，随机取6只作为正常对照组，60只制作成脊髓打击伤动物模型。模型大鼠随机分为甲基强的松龙组和治疗对照组，每组30只，分别于伤后1、3、7、14和28d取材，应用免疫组织化学方法观察MAP-2的表达，用改良的Tarlov评分观察大鼠脊髓损伤后运动功能的恢复情况。结果大鼠脊髓损伤后7和14d，甲基强的松龙组MAP-2的表达强于治疗对照组；大鼠脊髓损伤后7、14和28d，甲基强的松龙组Tarlov评分大于治疗对照组。结论甲基强的松龙能促进大鼠损伤脊髓表达MAP-2，并能促进大鼠脊髓损伤后运动功能的恢复。 |
| 关 键 词： | 脊髓损伤 甲基强的松龙 微管相关蛋白-2 |
Effects of methylprednisolone on the expression of microtubule associated protein-2 after spinal cord injury in rats |
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| MA Yan-chao,DONG Ping,QIAN Jun,HAN Hua,WANG Yu-liang. Effects of methylprednisolone on the expression of microtubule associated protein-2 after spinal cord injury in rats[J]. Journal of Lanzhou University (Medical Sciences), 2010, 36(1): 1-4 | |
| Authors: | MA Yan-chao DONG Ping QIAN Jun HAN Hua WANG Yu-liang |
| Affiliation: | 1.Department of Orthopaedics/a>;Second Hospital of Lanzhou University/a>;Lanzhou 730030/a>;China/a>;2.Department of Orthopaedics/a>;People's Hospital of Zhangye City/a>;Zhangye 734000/a>;Gansu/a>;China |
| Abstract: | Objective To investigate the effects of methylprednisolone on the expression of microtubule associated protein-2(MAP-2) after spinal cord injury in rats.Methods Six rats were selected randomly from 66 adult healthy Wistar rats as the normal control group,and the rest was divided into two groups after contusion injury was performed:methylprednisolone group and treatment control group,30 rats for each group.On the day 1,3,7,14 and 28 after injury,the rats were killed,the expression of MAP-2 was detected with ... |
| Keywords: | spinal cord injury methylprednisolone microtubule associated protein-2 |
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