| 冻干法制备法罗培南钠口腔崩解片的研究 |
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| 作者姓名： | 朱姚亮 陈小伟 郝贵周 |
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| 作者单位： | 鲁南制药集团股份有限公司，国家手性制药工程技术研究中心，山东 临沂 276006 |
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| 基金项目： | 国家科技支撑计划(2014BAI16B00) |
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| 摘 要： | 目的：优化法罗培南钠口腔崩解片的处方，并进行体外溶出测定。方法采用冻干法进行法罗培南钠口腔崩解片的制备，以崩解时间、脆碎度及溶出度为考察指标，采用正交设计进行处方优化。结果按优化处方制备的口腔崩解片口感良好、崩解迅速、脆碎度小，3 min 体外溶出达95％以上。结论本处方可制备质量优良的法罗培南钠口腔崩解片。
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| 关 键 词： | 法罗培南钠 口腔崩解片 冻干法 |
Preparation of Sodium Faropenem Orally Disintegrating Tablets by freeze-dried methods |
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| Authors: | ZHU Yaoliang CHEN Xiaowei and HAO Guizhou |
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| Institution: | Lunan Pharmaceutical Group Co.,Ltd.,National Egineering Research Center of Chiral Durgs,Linyi 276006,China,Lunan Pharmaceutical Group Co.,Ltd.,National Egineering Research Center of Chiral Durgs,Linyi 276006,China and Lunan Pharmaceutical Group Co.,Ltd.,National Egineering Research Center of Chiral Durgs,Linyi 276006,China |
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| Abstract: | Objective To optimize the formulation of Sodium Faropenem Orally Disintegrating Tablets and detect the dissolution in vitro. Methods Sodium Faropenem Orally Disintegrating Tablets was prepared by freeze - dried methods, and the formulation was optimized with the disintegrating time,friability and dissolution rate as parameters by orthogonal de-sign. Results The tablets prepared by optimum formulation were well - tasted,disintegrating fast,and had low friability. The dissolution was up to 95% within 3 min in vitro. Conclusion Sodium Faropenem Orally Disintegrating Tablets can be prepared successfully using the formulation in this research. |
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| Keywords: | Sodium faropenem Orally disintegrating tablets Freeze - dried methods |
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