变应性鼻炎舌下含服粉尘螨滴剂免疫治疗早期鼻分泌物嗜酸细胞检测与临床分析

目的 探讨变应性鼻炎舌下含服粉尘螨滴剂免疫治疗早期鼻分泌物嗜酸细胞计数及与临床症状的关系。方法 对43例行舌下含服粉尘螨滴剂免疫治疗的变应性鼻炎患者，在免疫治疗前及治疗后2、4、8周采集鼻腔分泌物，经涂片染色后计数鼻分泌物嗜酸细胞，并分析其与临床症状的可能相关性。结果 舌下含服粉尘螨滴剂免疫治疗后4、8周鼻分泌物嗜酸细胞计数较免疫治疗前下降，差异有统计学意义（P<0.05）；免疫治疗后4周及8周主观症状有明显改善的患者鼻分泌物嗜酸细胞计数较免疫治疗前下降，差异有统计学意义（P<0.05）。结论 舌下含服粉尘螨滴剂治疗变应性鼻炎时，鼻黏膜局部免疫状态的改变在免疫治疗后4周或更早的时间已经发生。

Detection of EOS in nasal section of the early stage in patients with allergic rhinitis treated with sublingual specific immunotherapy

Objective To explore the relationship in early stage between EOS in the nasal section and clinic syndromes in patients with allergic rhinitis treated with sublingual specific immunotherapy. Methods 43 patients with allergic rhinitis treated with sublingual specific immunotherapy were enrolled in this study. EOS account in the nasal sections was carried out before the treatment and 2,4 and 8 weeks after the treatment. Result After 4 and 8 weeks, expression of EOS in the nasal section in all cases and in cases with alleviation of clinic syndromes was statistically decreased（P<0.05）. Conclusion The local immune status of nasal mucosa has been changed after 4 week sublingual immunotherapy in patients with allergic rhinitis.