| 形觉剥夺性近视中巩膜变化的生物学机制 |
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| 引用本文： | 朱玉广,刘双珍.形觉剥夺性近视中巩膜变化的生物学机制[J].眼科新进展,2003,23(1):48-51. |
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| 作者姓名： | 朱玉广 刘双珍 |
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| 作者单位： | 410078,湖南长沙,中南大学湘雅医院眼科 |
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| 摘 要： | 近视眼的发病机制不明，形觉剥夺可以诱导典型的近视动物模型，形成形觉剥夺性近视眼(form—deprivationmyopia，FDM)。通过细胞和分子水平的研究发现，FDM的变化主要表现在眼球局部，形觉剥夺可诱导巩膜软骨细胞增殖，细胞外基质(extracellularmaterial，ECM)基因表达异常，ECM增加，巩膜胶原纤维改变等引起巩膜重塑，导致眼轴延长，近视屈光度增加。本文就FDM巩膜变化生物学机制的研究进展作一综述。
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| 关 键 词： | 形觉剥夺性近视 巩膜变化 生物学机制 动物模型 FDM |
| 文章编号： | 1003-5141(2003)01-0048-01 |
| 修稿时间： | 2002年7月15日 |
Regulation mechanism of sclera remodeling in form-deprivation myopia |
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| ZHU Yu Guang,LIU Shuang Zhen.Regulation mechanism of sclera remodeling in form-deprivation myopia[J].Recent Advances in Ophthalmology,2003,23(1):48-51. |
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| Authors: | ZHU Yu Guang LIU Shuang Zhen |
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| Abstract: | Visual input may play an important role in regulating the eyeball growth during maturation. Form deprivation can cause the deprived eye to become axially myopic and eye enlargement. Form deprivation myopia(FDM) is restricted to the retinal region that had been form deprived. FDM results in the scleral thinning and changes in the diameter of scleral collagen fibrils and causes an increased production of extracellular matrix with an increased level of mitotic activity in the cartilaginous sclera.We review the related articles to evaluate the regulation mechanism of sclera remodeling. |
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| Keywords: | form deprivation myopia sclera remodeling regulation mechanism |
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