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| 缺锌和补锌对大鼠脂质过氧化及抗氧化系统的影响 | |
| 引用本文： | 周丽丽 樊晶先. 缺锌和补锌对大鼠脂质过氧化及抗氧化系统的影响[J]. 中国公共卫生学报, 1995, 14(2): 113-115 |
| 作者姓名： | 周丽丽 樊晶先 |
| 作者单位： | 山西医学院第一附属医院，山西医学院预防医学系 |
| 摘 要： | 健康雄性Ｗｉｓｔａｒ大鼠４５只，先进行２５天锌缺乏实验，而后２１只大鼠再进行１５天补锌治疗实验。结果显示，缺锌可致大鼠红细胞超氧化物歧化酶（ＳＯＤ）活性、全血谷胱甘肽过氧化物酶（ＧＳＨＰｘ）活性及还原型谷胱甘肽（ＧＳＨ）含量明显下降．而血清过氧化脂质（ＬＰＯ）含量显著升高。补锌１２．３０或２５０ｐｐｍ均可使原缺锌大鼠的各项指标完全恢复，并且血清锌含量与上述各项指标均呈明显的相关关系。结果提示，缺锌可致大鼠抗氧化能力减弱．脂质过氧化反应增强．且补锌治疗时．一个ＲＤＡ（推荐的每日膳食营养素供给量）剂量即可使大鼠体内氧化与抗氧化之间的平衡完全恢复。 |
| 关 键 词： | 缺锌；补锌治疗；脂质过氧化；抗氧化系统 |
Influence of Zinc Deficiency and Supplement of Zinc on Lipid Peroxidation and Antioxidantion System in Rats |
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| Zhou Lin. et al.,. Influence of Zinc Deficiency and Supplement of Zinc on Lipid Peroxidation and Antioxidantion System in Rats[J]. , 1995, 14(2): 113-115 | |
| Authors: | Zhou Lin. et al. |
| Affiliation: | First Affiliated Hospital of Shanxi Medical College Taiyuan 030001 |
| Abstract: | Effects of Zinc deficiency and supplement on lipid peroxidation and antioxidants were studied in adult male rats. The results showed that the superoxide dismutase(SOD)activity in red blood cells. the glutathione peroxidase (GSH-PX )activity and reduced glutathione(GSH) content in whole blood decreased significantly .while the lipid peroxide(LPO)content increased markedly in Zn-deficient rats. And good correlations were found between the parameters observed returned to normal by supplying 12. 30 or 25O ppm zinc. These results suggested that zinc deficiency could lead to decrease of capacity of antioxidation and increase of lipid peroxidation .and one RDA zinc supplement was cnough to re-establish the balance between oxidation and antioxidation in Zn-deficient rats. |
| Keywords: | Zinc deficiency Zinc supplement Lipid peroxidation Antioxidant |
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