| 青藤碱衍生物的合成及其抗炎镇痛活性青藤碱衍生物的合成及其抗炎镇痛活性 |
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| 引用本文： | 叶仙蓉,颜克序,吴克美,冯孝章,黄宇明,仇萍. 青藤碱衍生物的合成及其抗炎镇痛活性青藤碱衍生物的合成及其抗炎镇痛活性[J]. 药学学报, 2004, 39(3): 180-183 |
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| 作者姓名： | 叶仙蓉 颜克序 吴克美 冯孝章 黄宇明 仇萍 |
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| 作者单位： | 1. 中国医学科学院、中国协和医科大学,药物研究所,北京,100050
2. 湖南正清制药集团股份有限公司,湖南,怀化,418000 |
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| 摘 要： | 目的为定向设计合成高效低毒的新一代青藤碱类药物提供线索。方法以青藤碱为先导物,对C环进行结构改造。结果共合成7个衍生物,进行了抗炎镇痛活性的筛选,结果表明,化合物2和5具有较好的抗炎镇痛作用。结论C环结构修饰值得进一步研究。
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| 关 键 词： | 青藤碱 抗炎 镇痛 |
| 收稿时间： | 2003-03-19 |
Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives |
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| YE Xian-rong,YAN Ke-xu,WU Ke-mei,FENG Xiao-zhang,HUANG Yu-ming,QIU Ping. Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives[J]. Acta pharmaceutica Sinica, 2004, 39(3): 180-183 |
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| Authors: | YE Xian-rong YAN Ke-xu WU Ke-mei FENG Xiao-zhang HUANG Yu-ming QIU Ping |
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| Affiliation: | Institute of Materia Medica Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. xianrongye@imm.ac.cn |
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| Abstract: | Aim To provide basic data for the synthesis of new sinomenine derivatives. Methods The C ring in sinomenine was modified. Results Seven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities. Conclusion Modification of the C ring in sinomenine should be worthy to be studied further. |
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| Keywords: | sinomenine anti-inflammatory analgesic |
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