Genetic Variations in FTSJ1 Influence Cognitive Ability in Young Males in the Chinese Han Population |
| |
| Authors: | Pingyuan Gong Jing Li Ling Dai Kejin Zhang Zijian Zheng Xiaocai Gao |
| |
| Affiliation: | 1. School of Life Science, Institute of Population and Health, Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) , Ministry of Education , Xi'an , China;2. School of Public Management, Institute of Application Psychology , Northwest University , Xi'an , China |
| |
| Abstract: | Human cognitive ability is a trait that is known to be significantly influenced by genetic factors. Previous linkage data provide evidence suggesting that gene FtsJ homolog 1 (Escherichia coli) is associated with mental retardation. The gene may have a relation to individual differences in cognitive ability because it is most critical for brain development. In the present research, three tag single-nucleotide polymorphism (SNPs) (rs2268954, rs2070991, and rs5905692) in FtsJ homolog 1 (E. coli) are selected and genotyped by the PCR-SSCP method. An analysis of variance is performed to determine the relationship between the SNPs and cognitive ability of the Chinese Han population of youth in Qinba mountain. There are significant correlations between the variance in FtsJ homolog 1 (E. coli) and general cognitive ability, verbal comprehension, and preceptual organization. These findings suggest that genetic variations in FtsJ homolog 1 (E. coli) possibly influence human cognitive ability. |
| |
| Keywords: | general cognitive ability FtsJ homolog 1 (E. coli) single-nucleotide polymorphism (SNP) analysis of variance mental retardation |
|
|
