参芪扶正注射液辅助治疗肺癌合并阻塞性肺部感染者的疗效及对血清细胞因子的影响

目的研究参芪扶正注射液辅助治疗肺癌合并阻塞性肺部感染者的疗效及对血清细胞因子的影响。 方法以2016年2月至2018年2月东莞市桥头医院收治的肺癌合并阻塞性肺部感染者104例为研究对象,以随机数字表法均分成研究组（52例）和对照组（52例）。对照组患者予以肺癌合并阻塞性肺部感染常规治疗。研究组患者则在对照组治疗基础上予以参芪扶正注射液辅助治疗。比较两组患者的临床疗效及相关临床指标,治疗前后血清降钙素原（PCT）、超敏C-反应蛋白（hs-CRP）、基质金属蛋白酶-9（MMP-9）、白细胞介素6（IL-6）及白细胞介素8（IL-8）水平,不良反应发生率。 结果研究组患者治疗总有效率为96.15%（50/52）,高于对照组[82.69%（43/52）],差异有统计学意义（χ² = 4.981、P = 0.026）。研究组患者体温复常时间、白细胞计数恢复时间、住院天数均低于对照组患者（t = 4.107、2.359、6.017,P均< 0.05）。治疗后研究组患者血清PCT、hs-CRP、MMP-9、IL-6及IL-8水平均低于对照组,差异均有统计学意义（t = 22.324、3.531、10.156、20.866、21.583,P均< 0.05）。研究组患者不良反应发生率显著低于对照组,差异有统计学意义（χ² = 4.727,P = 0.030）。 结论参芪扶正注射液辅助治疗肺癌合并阻塞性肺部感染者的疗效显著,有利于促进患者康复,同时可有效降低血清细胞因子水平,安全性较好。

Effects of Shenqi fuzheng injection for treatment of patients with lung cancer and obstructive pulmonary infection and its effects on serum cell cytokine

ObjectiveTo investigate the effect of Shenqi Fuzheng injection on serum cytokines in patients with lung cancer complicated with obstructive pulmonary infection. MethodsTotal of 104 patients with lung cancer complicated with obstructive pulmonary infection treated in Qiaotou Hospital of Dongguan City from February 2016 to February 2018 were collected, and were randomly divided into study group (52 cases) and control group (52 cases). The patients in control group were treated with routine treatment for lung cancer and obstructive pulmonary infection, while patients in study group were treated with Fuzheng injection for adjuvant treatment on the basis of routine treatment. Clinical efficacy and related clinical indexes such as the levels of procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP), matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-8) and interleukin-8 (IL-8) in serum of patients in both groups before and after treatment, and adverse reaction rate were compared, respectively. ResultsThe total effective rate was 96.15% (50/52) of patients in study group, which was significantly higher than that of the control group [82.69% (43/52)], with significant differences (χ² = 4.981, P = 0.026). The recovery period of body temperature and white blood cell count, the hospital stay period of patients in study group were shorter than those of the control group (t = 4.107, 2.359, 6.017; all P < 0.05). The levels of serum PCT, hs-CRP, MMP-9, IL-6 and IL-8 of patients in study group were significantly lower than those of control group after treatment, with significant differences (t = 22.324, 3.531, 10.156, 20.866, 21.583; all P < 0.05). The incidence of adverse reactions of patients in study group was significantly lower than that of the control group, with significant differences (χ² = 4.727, P = 0.030). ConclusionsShenqi fuzheng injection is effective in the treatment of lung cancer complicated with obstructive pulmonary infection. It is beneficial to the rehabilitation of patients with lung cancer and could effectively reduce the level of serum cytokines with good security.