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| 特应性皮炎患者外周血细胞亚群DC1/DC2、Th1/Th2检测的临床意义 | |
| 引用本文： | 唐勇,吴吉芳. 特应性皮炎患者外周血细胞亚群DC1/DC2、Th1/Th2检测的临床意义[J]. 标记免疫分析与临床, 2009, 16(5): 278-280 |
| 作者姓名： | 唐勇 吴吉芳 |
| 作者单位： | 海南省三亚市人民医院检验科,海南,三亚,572000;海南省三亚市人民医院检验科,海南,三亚,572000 |
| 摘 要： | 为探讨特应性皮炎（AD）患者外周血细胞亚群DC（DC1/DC2）与细胞亚群Th（Th1/Th2）分化状态及其临床意义,采用免疫荧光三标记流式细胞术检测35例特应性皮炎患者外周血DC1/DC2亚群（DC1/CD11 c＋和DC2/CD123＋）、Th1/Th2亚群（CD3＋CD4＋CD30-/CD3＋CD4＋CD30＋）,并以35名正常人作为对照组。结果表明,特应性皮炎患者DC CD123＋百分率比对照组明显增高（P＆lt;0.05）,而CD11 c＋DC百分率与对照组相比,无统计学意义（P＆gt;0.05）;Th2（CD3＋CD4＋CD30＋）显著增高（P＆lt;0.05）,Th1亚型（CD3＋CD4＋CD30-）与对照组比较,差异无统计学意义（P＆gt;0.05）。特应性皮炎患者外周血细胞亚群DC2呈优势,导致向细胞亚群Th2的免疫反应偏移,这可能与特应性皮炎的发病有关。 |
| 关 键 词： | 特应性皮炎 细胞亚群(DC1/DC2 Th1/Th2) 外周血 流式细胞术 |
Clinical Significance of Detection of DC1/DC2 and Th1/Th2 Subsets in Peripheral Blood in Patients with Atopic Dermatitis |
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| TANG Yong,WU Ji-fang. Clinical Significance of Detection of DC1/DC2 and Th1/Th2 Subsets in Peripheral Blood in Patients with Atopic Dermatitis[J]. Labeled Immunoassays and Clinical Medicine, 2009, 16(5): 278-280 | |
| Authors: | TANG Yong WU Ji-fang |
| Affiliation: | TANG Yong,WU Ji-fang(Department of Clinical Lab,Sanya People's Hospital,Sanya 572000,China) |
| Abstract: | To determine the peripheral blood dendritic cell subsets(DC1/DC2) and Th cell subsets(Th1/Th2) in patients with atopic dermititis(AD) and explore their clinical significance,the peripheral blood DC1/DC2(DC1 /CD11c+ and DC2/CD123+),Th1/Th2(CD3+CD4+CD30-and CD3+CD4+CD30+) from 35 AD patients and 35 healthy controls were analyzed by flow cytometry with three-color immunofluorescent staining.The results showed that DC(DC2 /CD123+) and the Th2(CD3+CD4+CD30+) were significantly increased in AD patients in compari... |
| Keywords: | Th1/Th2) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |